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X-Ray Analysis of Polypeptide Hormones at ≦1Å Resolution: Anisotropic Thermal Motion and Secondary Structure of Pancreatic Polypeptide and Deamino-Oxytocin

  • A. C. Treharne
  • S. P. Wood
  • I. J. Tickle
  • J. E. Pitts
  • J. Husain
  • I. D. Glover
  • S. Cooper
  • T. L. Blundell
Part of the NATO ASI Series book series (NSSA, volume 126)

Abstract

Polypeptide hormones are synthesised as larger precursors and stored in endocrine cells from which they are released into the circulation in response to peptide factors, metabolite levels and other agents. At target tissues they bind specific cell surface receptors which give rise to intracellular secondary effects such as changes in the levels of cAMP, tyrosine phosphorylation, etc. Their degradation is rapid and is often mediated by internalisation of the hormone-receptor complex. The role of the conformation of polypeptide hormones during this complex series of events may help in our understanding of the various processes at the molecular level.

Keywords

Pancreatic Polypeptide Disulphide Bridge Polypeptide Hormone Specific Cell Surface Receptor Large Precursor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • A. C. Treharne
    • 1
  • S. P. Wood
    • 1
  • I. J. Tickle
    • 1
  • J. E. Pitts
    • 1
  • J. Husain
    • 1
  • I. D. Glover
    • 1
  • S. Cooper
    • 1
  • T. L. Blundell
    • 1
  1. 1.Laboratory of Molecular Biology, Department of Crystallography, Birkbeck CollegeUniversity of LondonLondonUK

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