Carcinogenic Effects of Inhaled Radionuclides
During the last two decades, a series of studies have been conducted at this Institute to examine the carcinogenic effects of inhaled radionuclides. A number of studies have been conducted with Beagle dogs exposed brieflv to aerosols of ß-emitters (90Y, 91Y, 14CE and 90Sr) and α-emitters (238Pu and 239pu) in particles having different in vivo solubilities. The exposure conditions have been varied to produce initial lung burdens ranging downward from those producing acute lethality to levels equivalent to maximum permissible lung burdens for man. Dependent upon the particle size, chemical element and solubility of the particles, the inhalation intakes have resulted in varying degrees of protracted radiation exposure of nasal cavity, lung, lung-associated lymph nodes, liver and skeleton. The animals have been observed for their life span and dose-related increases in cancer have been observed in the most heavily irradiated sites. Although some of the studies are still in progress, sufficient data is at hand to provide cancer risk estimators for a number of radiation exposure scenarios. Some exposed animals are still surviving and may provide material for studies that will aid in providing bridges between observations in molecular and cellular systems, whole animals and people.
KeywordsLiver Cancer Nasal Cavity Bone Cancer Relative Biological Effectiveness Beta Emitter
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- 1.R. O. McClellan, B. B. Boecker, F. H. Hahn, and B. A. Muggenburg, “Lovelace ITRI studies on the toxicity of inhaled radionuclides in Beagle dogs,” In “Life-span Radiation Effects Studies in Animals: What Can They Tell Us? ”, (R. C. Thompson and J. A. Mahaffey, eds.), CONF830951, pp. 7496, 1986.Google Scholar
- 4.F. F. Hahn, B. A. Muggenburg, B. B. Boecker, R. G. Cuddihy, W. C. Griffith, R. A. Guilmette, R. O. McClellan, and J. A. Mewhinney, “Insights into radionuclide-induced lung cancer in people from life span studies in Beagle dogs, ”in: “Life-Span Radiation Effects Studies in Animals: What Can They Tell Us? ”, (R. C. Thompson and J. A. Mahaffey, eds.), CONF830951, pp. 521534, 1986Google Scholar
- 5.R. G. Cuddihy, Risks of radiation-induced lung cancer, in: “Critical Issues in Setting Radiation Dose Limits,” NCRP Proceedings No. 3 (1983), pp. 133-152.Google Scholar
- 6.B. A. Muggenburg, B. B. Boecker, F. F. Hahn, and R. O. McClellan, “The risk of liver tumors in dogs and man from radioactive aerosols,” in: “Life-Span Radiation Effects Studies in Animals: What Can They Tell Us? ”, (R. C. Thompson and J. A. Mahaffey, eds.), CONF830951, pp. 556563, 1986.Google Scholar
- 7.BEIR, “The Effects on Populations of Exposure to Low Levels of Ionizing Radiations,” National Academy Press, Washington, DC (1980), pp. 372-384.Google Scholar
- 8.M. E. Wrenn, Research in Radiobiology, in: “Annual Report of Work in Progress in the Internal Irradiation Program,” University of Utah, U.S. Department of Energy Report, COO-119-256 (1981).Google Scholar
- 9.B. B. Boecker, F. F. Hahn, R. G. Cuddihy, M. B. Snipes, and R. O. McClellan, “Is the Human Nasal Cavity at Risk from Inhaled Radionuclides?”, in: “Life-Span Radiation Effects Studies in Animals: What Can They Tell Us? ”, (R. C. Thompson and J. A. Mahaffey, eds.), CONF83091, pp. 564577, 1986.Google Scholar