Radiation Carcinogenesis and the Hair Follicle

  • I. P. Sinclair
  • F. J. Burns
Part of the NATO ASI Series book series (NSSA, volume 124)


Rodent skin has been used extensively as an experimental model for studying radiation carcinogenesis. The advantages of skin for such studies include: radiation beams can be localized in the target tissue without irradiating the whole animal, and tumors can be detected at an early stage of development and followed for long periods of time. The fact that rodent skin has been widely utilzed for testing carcinogenic chemicals permits comparisons of carcinogenesis by radiation and chemicals. The skin of albino rats responds to the carcinogenic action of several known human carcinogens, including, ionizing radiation and ultraviolet light.


Hair Follicle Electron Radiation Hair Growth Tumor Incidence Relative Biological Effectiveness 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • I. P. Sinclair
    • 1
  • F. J. Burns
    • 2
  1. 1.St. Josephs HospitalPatersonUSA
  2. 2.N.Y.U. Department of Environmental MedicineNew YorkUSA

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