Radiation Carcinogenesis and the Hair Follicle
Rodent skin has been used extensively as an experimental model for studying radiation carcinogenesis. The advantages of skin for such studies include: radiation beams can be localized in the target tissue without irradiating the whole animal, and tumors can be detected at an early stage of development and followed for long periods of time. The fact that rodent skin has been widely utilzed for testing carcinogenic chemicals permits comparisons of carcinogenesis by radiation and chemicals. The skin of albino rats responds to the carcinogenic action of several known human carcinogens, including, ionizing radiation and ultraviolet light.
KeywordsHair Follicle Electron Radiation Hair Growth Tumor Incidence Relative Biological Effectiveness
Unable to display preview. Download preview PDF.
- 10.F. J. Burns and R. E. Albert, “Radiation carcinogenesis in rat skin,” In: Radiation Carcinogenesis (eds., A. C. Upton, R. E. Albert, F. J. Burns and R. E. Shore) Elsevier, New York, 1986, pp. 199–214.Google Scholar
- 11.I. P. Sinclair, “The effect of penetration depth on radiation carcinogenesis in growing phase skin. ” Ph. D. thesis, New York University, 1974.Google Scholar