The Dependence of Dose-Effect Relations for Various Responses in Mammalian Cells on Radiation Quality, Implications for Mechanisms of Carcinogenesis
The induction and expression of malignant properties of cells, initiated by radiation or by other agents, involves a complex sequence of events. Some of the early processes can be studied with cells in culture which can be transformed by various treatments. The transformed characteristics are expressed as irregular growth, loss of contact inhibition and anchorage independence. Other processes required for the development of tumours, e. g., angiogenesis, and modification of tumour growth by immunological, hormonal or other factors, can only be studied in intact animals or in man. The analysis and interpretation of dose-effect relationships for radiation carcinogenesis must take into account physical, chemical, cellular and tissue factors which determine responses to this agent. In this cont ribution I want to discuss in particular some of the characteristic parameters of dose-response relationships which depend on energy deposition characteristics of ionizing radiations. These parameters have been determined for effects in cells, but they are in various aspects relevant for dose-effect relations for the development of tumours observed after irradiation.
KeywordsFast Neutron Chromosome Aberration Linear Energy Transfer Centric Ring Morphological Transformation
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