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The Dependence of Dose-Effect Relations for Various Responses in Mammalian Cells on Radiation Quality, Implications for Mechanisms of Carcinogenesis

  • G. W. Barendsen
Part of the NATO ASI Series book series (NSSA, volume 124)

Abstract

The induction and expression of malignant properties of cells, initiated by radiation or by other agents, involves a complex sequence of events. Some of the early processes can be studied with cells in culture which can be transformed by various treatments. The transformed characteristics are expressed as irregular growth, loss of contact inhibition and anchorage independence. Other processes required for the development of tumours, e. g., angiogenesis, and modification of tumour growth by immunological, hormonal or other factors, can only be studied in intact animals or in man. The analysis and interpretation of dose-effect relationships for radiation carcinogenesis must take into account physical, chemical, cellular and tissue factors which determine responses to this agent. In this cont ribution I want to discuss in particular some of the characteristic parameters of dose-response relationships which depend on energy deposition characteristics of ionizing radiations. These parameters have been determined for effects in cells, but they are in various aspects relevant for dose-effect relations for the development of tumours observed after irradiation.

Keywords

Fast Neutron Chromosome Aberration Linear Energy Transfer Centric Ring Morphological Transformation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • G. W. Barendsen
    • 1
    • 2
  1. 1.Radiobiological Institute TNORijswijkThe Netherlands
  2. 2.Laboratory for RadiobiologyAmsterdamThe Netherlands

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