Visible Light Induced Killing and Mutation of Acriflavine Sensitized Chinese Hamster Cells
The acridine dyes are perhaps the most well studied photosensitizers both in vivo and in vitro. Exhaustive in vivo studies with these dyes have been made only with bacteria and bacteriophages but not with mammalian cells. The photodynamic effects in mammalian cells have been investigated mainly with the drugs hematoporphyrin, furocoumarins like 8-methoxypsoralen and chlorpromazine (6, 2, 1). Basic information regarding the target of visible light induced damage as well as the mechanism by which this damage occurs in acriflavine sensitized mammalian cells is important due to the application of these dyes in photochemotherapy.
KeywordsSinglet Oxygen Sodium Azide Washed Cell Chinese Hamster Cell Streptomycin Sulphate
Unable to display preview. Download preview PDF.