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The Role of Oncogenes in Multistage Carcinogenesis

  • K. Brown
  • M. Quintanilla
  • M. Ramsden
  • A. Balmain
Part of the NATO ASI Series book series (NSSA, volume 124)

Abstract

The existence of specific genes which could transform normal cells into tumour cells was first demonstrated in studies of retroviruses isolated from avian or rodent tumours (1). The prototype oncogene is the src gene of the avian Rous Sarcoma virus. This virus induces tumours with a short latent period in chickens and it has been demonstrated using temperature sensitive mutants that the sre gene has to be expressed in order that transformation should occur (2). Over twenty additional oncogenes have subsequently been discovered in different retrovirus isolates. The products of these oncogenes can be classified into several categories according to their cellular localization or biochemical function as tyrosine kinases (src family) or GTP-binding proteins (ras family). The biological role of these products in cellular transformation is unknown, and the only oncogenes to which a function has been ascribed are those related to growth factors (sis gene) or growth factor receptors (erb B gene). Some oncogenes, for example those belonging to the ras family or the myc gene, have been isolated on several occasions in entirely independent viruses, suggesting that they play a very important role in tumour induction.

Keywords

Animal Model System Cellular Oncogene Multistage Carcinogenesis Murine Sarcoma Virus Skin Papilloma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • K. Brown
    • 1
  • M. Quintanilla
    • 1
  • M. Ramsden
    • 1
  • A. Balmain
    • 1
  1. 1.Beatson Institute for Cancer ResearchGarscube EstateGlasgowScotland

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