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The Induction and Repair of Ultraviolet Light Damage in Mammalian Cells

  • A. M. Rauth
Part of the NATO ASI Series book series (NSSA, volume 124)

Abstract

Ultraviolet light (UV) has been extensively used as a damage inducing agent in mammalian cells in in vitro cell cultures. The wavelengths studied have been primarily in the range of 200-300 nm where deoxyribonucleic acid (DNA) absorbs most strongly. In the present article a review will be made of the major effects of UV in this wavelength range on such in vitro systems in terms of: (1) damage production; (2) cell survival and mutation; (3) the role of various repair processes in modifying the induced damage; and, finally, (4) the carcinogenic process. An attempt will be made to indicate to some degree where these effects of UV differ from those of ionizing radiation and to point out some unique features of mammalian cells compared to bacterial systems where the models for understanding UV effects have originated. Due to the breadth of the material covered, extensive reference has been made to review articles which summarize the original work. The references cited are in no way complete and only represent an introduction to the original literature. In particular, extensive use of the following reviews has been made (1-11).

Keywords

Mammalian Cell Excision Repair Xeroderma Pigmentosum Chinese Hamster Cell Pyrimidine Dimer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • A. M. Rauth
    • 1
  1. 1.Physics Division Ontario Cancer Institute Department of Medical BiophysicsUniversity of TorontoTorontoCanada

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