Actions of Intravenous Eserine and Pyridostigmine on Cat Spinal Cord Renshaw Cells
Protection from irreversible inhibition of cholinesterases (ChE) is afforded by pretreatment with a carbamate such as physostigmine (Koelle, 1946, 1957). This tertiary drug readily gains access to the CNS, and it has been shown to raise the LD50 in rats when given prior to toxic doses of potent, centrally acting irreversible inhibitors of ChEfs. Some protection from exposure to centrally-acting irreversible anticholinesterases (antiChE) also has been reported following pretreatment with pyridostigmine, a quaternary carbamate (Wolthuis and Vanwersch, 1984). Using indirect observations, these authors propose a CNS action of pyridostigmine.
KeywordsAtropine Sulfate Renshaw Cell Time Interval Histogram Methyl Nitrate Antidromic Stimulation
Unable to display preview. Download preview PDF.
- Eccles, J.C., Fatt, P. and Koketsu, K, 1956, Cholinergic and inhibitory synapses in a pathway from motor-axon collaterals to motoneurons. J. Physiol.(London) 126: 524–562.Google Scholar
- Eccles, J.C., Eccles, R.M. and Fatt, P., 1956, Pharmacological investigations on a central synapse operated by acetylcholine, J. Physiol. (London) 131: 154–169.Google Scholar