The Effects of 2,5-Hexanedione on Cholinesterase in the Rat

  • Barbara F. Bass
  • Alan M. Goldberg


Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are two enzymes that are important because of the role they play in neurotransmission and metabolism of exogenous and endogenous substrates. While both enzymes hydrolyze acetylcholine (ACh), they do so at significantly different rates, AChE being approximately 10X faster (Main, 1976). Both are glycoproteins and exist in homologous sets of six molecular forms, three globular and three asymmetric (Massoulie and Bon, 1982; Vigny et al., 1978). The globular forms consist of the catalytic subunit as a monomer (G1), a dimer (G2), and tetramer (G4). The asymmetric forms are composed of one (A4), two (A8), and three (A12) tetramers attached to a collagen tail. The composition of the molecular forms varies from tissue to tissue as well as from species to species.


Soleus Muscle AChE Activity Axonal Transport Molecular Form Tibial Nerve 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Barbara F. Bass
    • 1
  • Alan M. Goldberg
    • 1
  1. 1.The Johns Hopkins School of Hygiene and Public HealthBaltimoreUSA

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