The Effects of 2,5-Hexanedione on Cholinesterase in the Rat
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are two enzymes that are important because of the role they play in neurotransmission and metabolism of exogenous and endogenous substrates. While both enzymes hydrolyze acetylcholine (ACh), they do so at significantly different rates, AChE being approximately 10X faster (Main, 1976). Both are glycoproteins and exist in homologous sets of six molecular forms, three globular and three asymmetric (Massoulie and Bon, 1982; Vigny et al., 1978). The globular forms consist of the catalytic subunit as a monomer (G1), a dimer (G2), and tetramer (G4). The asymmetric forms are composed of one (A4), two (A8), and three (A12) tetramers attached to a collagen tail. The composition of the molecular forms varies from tissue to tissue as well as from species to species.
KeywordsSoleus Muscle AChE Activity Axonal Transport Molecular Form Tibial Nerve
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- Cangiano, A., Lutzemberger, L., Rizzuto, N., Simomati, A., Rossi, A., and Toschi, G. (1980) Neurotoxic effects of 2,5-hexanedione in rats: early morphological and functional changes in nerve fibres and neuromuscular junctions. Neurotoxicology 2: 25–32.Google Scholar
- Di Giamberardino, L., and Couraud, J. Y. (1981) Acetylcholinesterase and butyrylcholinesterase: similarities in normal and denervated muscles, differences in axonal transport. In: “Cholinergic Mechanisms”. (Eds.) Pepue, G., and Ladinsky, H. Plenum Press, New York, pp. 387–392.Google Scholar
- Drachman, D. B. (1976) Trophic interactions between nerves and muscles: the role of cholinergic transmission (including usage) and other factors. In: “Biology of Cholinergic Function”. (Eds.) Goldberg, A. M., and Hanin, I. Raven Press, New York, pp. 161–186.Google Scholar
- Main, A. R. (1976) Structure and inhibitors of cholinesterase. In: “Biology of Cholinergic Function”. (Eds.) Goldberg, A. M. and Hanin, I. Raven Press, New York, pp. 269–353.Google Scholar
- Spencer, P. S., and Schaumburg, H. H. (1978) Pathobiology of neurotoxic axonal degeneration. In: “Physiology and Pathobiology of Axons”. (Ed.) Waxman, S. G. Raven Press, New York, pp. 265–282.Google Scholar