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Organophosphate Poisoning and its Treatment by Oximes

  • P. G. Waser
  • C. G. Caratsch
  • A. Chang Sin-Ren
  • W. Hopff
  • A. Gotheil
  • E. Kaiser
  • R. Sammet
  • C. Streichenberg

Abstract

In our last report in Oglebay Park (Waser et al., 1983) we described the poisoning of animals with 14C-labeled sarin and its kinetics. We demonstrated the low antitoxic activity of pralidoxime and obidoxime injected 2–60 minutes after the poisoning, but causing a marked decrease of radioactivity when injected 20 minutes before 14C-sarin. We will report here on the kinetics and distribution of another organophosphate, 32P-diisopropyl-fluorophosphonate (DFP) (phosphofluoridic acid bis (1-methylethyl) ester) in mice. The interaction between sarin and obidoxime or pralidoxime (2-PAM) will be described, and possible mechanisms of reactivation of the phosphorylated enzyme, or of antagonizing the overflowing acetylcholine will be discussed.

Keywords

Cholinergic Receptor Fluoro Phosphate Organophosphate Poisoning Frog Neuromuscular Junction Iontophoretical Application 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • P. G. Waser
    • 1
  • C. G. Caratsch
    • 1
  • A. Chang Sin-Ren
    • 1
  • W. Hopff
    • 1
  • A. Gotheil
    • 1
  • E. Kaiser
    • 1
  • R. Sammet
    • 1
  • C. Streichenberg
    • 1
  1. 1.Institute of PharmacologyUniversity of ZürichZürichSwitzerland

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