Abstract
In 1946 there was published both the synthesis of the archetypal organophosphorus cholinesterase inhibitor, DFP,1 and the finding of an enzyme that hydrolyzes and thus detoxifies this compound.2 In 1963, in the same landmark volume to which Karczmar contributed two chapters on particular aspects of the acetylcholine system often elucidated by the use of DFP,3,4 Mounter5 reviewed the subject that has come to be known as “DFPase”. While a relationship of a compound that is an inhibitor of cholinesterase to an enzyme that hydrolyzes that compound will be self-evident, every imaginable aspect of the one enzyme is either understood or under study, whereas the other enzyme, seemingly without natural substrate or physiological role, may require some introduction.
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References
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© 1987 Plenum Press, New York
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Hoskin, F.C.G., Reese, E.T., Smith, W.J. (1987). Mipafox — Inhibitor of Cholinesterase, Neurotoxic Esterase, and DFP-ase: Is there a “Mipafox-ase”?. In: Dun, N.J., Perlman, R.L. (eds) Neurobiology of Acetylcholine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5266-2_36
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DOI: https://doi.org/10.1007/978-1-4684-5266-2_36
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