Succinylcholine — Clinical and Toxicological Aspects

  • Bo Holmstedt
  • Ingrid Nordgren
  • Gun Jacobsson
  • Inga Jäderholm-Ek
  • Torsten Silander


The history of succinylcholine (SCh) from 1906 up to date has been well documented by Dorkins (1982). It was introduced as a muscle relaxant by several groups around 1950. Its short lasting effect made it ideal for intubation before surgery. For prolonged muscle relaxation it has been largely superseded by other synthetic compounds. Untoward effects have been noted, such as prolonged apnea, cardiovascular effects and muscle fasciculations. In 1954 SCh was introduced in veterinary medicine as a casting agent for large animals (Hansson and Edlund, 1954; Hansson, 1958).


Human Plasma Clinical Dose Muscle Fasciculation Artificial Respiration Plasma Cholinesterase Activity 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Bo Holmstedt
    • 1
  • Ingrid Nordgren
    • 1
  • Gun Jacobsson
    • 1
  • Inga Jäderholm-Ek
    • 2
  • Torsten Silander
    • 3
  1. 1.Department of ToxicologyKarolinska InstitutetStockholmSweden
  2. 2.Department of AnaesthesiaErsta HospitalStockholmSweden
  3. 3.Department of SurgeryErsta HospitalStockholmSweden

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