Cholinergic Systems in the Central Control of Body Temperature

  • R. D. Myers


By the mid-1960’s, it had become apparent that specific nerve cells in the anterior hypothalamus (AH) and pre-optic area (POA) are delegated to the primary physiological mechanisms underlying the control of body temperature (Boulant, 1980). On the basis of pharmacological studies, it was postulated in this era that serotonin (5-HT)-containing neurons within the AH/POA released 5-HT in order to activate the neuronal mechanism for heat production (Feldberg and Myers, 1964). Conversely, noradrenergic neurons within the same anatomical region were hypothesized to liberate norepinephrine (NE) at their synapses to activate the functional system for heat dissipation. However, a missing link in this “monoamine theory” centered on the neurohumoral nature of the anatomical pathways that necessarily mediate the distinct physiological signals emanating from the AH/POA for either the loss or production of body heat (Myers, 1969).


Core Temperature Heat Production Heat Gain Cerebral Ventricle Body Heat 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • R. D. Myers
    • 1
    • 2
    • 3
  1. 1.Department of PsychiatryUniversity of North Carolina School of MedicineChapel HillUSA
  2. 2.Department of PharmacologyUniversity of North Carolina School of MedicineChapel HillUSA
  3. 3.Center for Alcohol StudiesUniversity of North Carolina School of MedicineChapel HillUSA

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