Cholinergic Regulation of REM Sleep: Basic Mechanisms and Clinical Implications for Affective Illness and Narcolepsy

  • Priyattam J. Shiromani
  • J. Christian Gillin


Rapid eye movement (REM) sleep was first discovered with the observation of a wake-like EEG associated with bursts of rapid eye movements during behavioral sleep in man. When subjects were awakened from this state, they were likely to report dreaming. Since then REM sleep has been discovered in virtually all mammals, some birds and, perhaps, in reptiles.


Dorsal Raphe Nucleus Paradoxical Sleep Cholinergic Mechanism Pontine Reticular Formation Arch Ital Biol 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Priyattam J. Shiromani
    • 1
  • J. Christian Gillin
    • 1
  1. 1.Department of Psychiatry (V-116A), VA Medical CenterUniversity of CaliforniaSan DiegoUSA

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