Aspects of Cholinergic Function in Amyotrophic Lateral Sclerosis

  • S.-M. Aquilonius
  • P.-G. Gillberg


The degenerative changes in amyotrophic lateral sclerosis (ALS) are preferentially restricted to the cortico-spinal tracts and to the lower motor neurons. Based on this mysterious selectivity, numerous theories regarding the etiology have been put forward, but none has so far been conclusively proved. However, irrespective of etiology, progressive neuronal degeneration should be accompanied by a disturbance of neurotransmission at the synapses of the fiber tracts involved.


Amyotrophic Lateral Sclerosis Motor Neuron Dorsal Horn Lower Motor Neuron Amyotrophic Lateral Sclerosis Case 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Aquilonius, S.-M., Eckernäs, S.-Å. and Gillberg, P.-G. (1981): Brain. Res. 211: 329–340.PubMedCrossRefGoogle Scholar
  2. 2.
    Aquilonius, S.-M., Askmark, H., Eckernäs, S.-Å., Gillberg, P.-G., Hilton-Brown, P., Rydin, E. and Stålberg, E. (1985): To be published.Google Scholar
  3. 3.
    Cuello, A., Polak, J. and Pearse, A. (1976): Lancet II: 1054–1056.Google Scholar
  4. 4.
    Gillberg, P.-G., Aquilonius, S.-M., Eckernäs, S.-Å., Lundqvist, G. and Winblad, B. (1982): Brain. Res. 250: 394–397.PubMedCrossRefGoogle Scholar
  5. 5.
    Gillberg, P.-G., Nordberg, A. and Aquilonius, S.-M. (1984): Brain. Res. 300: 327–333.PubMedCrossRefGoogle Scholar
  6. 6.
    Gillberg, P.-G. (1985): Thesis Acta Universitatis Upsaliensis, Almqvist & Wiksell International, Stockholm, Sweden.Google Scholar
  7. 7.
    Gillberg, P.-G. and Aquilonius, S.-M. (1985): Accepted Acta Neurol. Scand.Google Scholar
  8. 8.
    Hayashi, H., Suga, M., Satake, M. and Tsubaki, T. (1981): Ann. Neurol. 9: 292–294.PubMedCrossRefGoogle Scholar
  9. 9.
    Houser, C.R., Crawford, G.D., Barber, R.P., Salvaterra, P.M. and Vaughn, J.E. (1983): Brain. Res. 266: 97–119.PubMedCrossRefGoogle Scholar
  10. 10.
    Ishii, T. and Friede, R.L. (1967): IN International Review of Neurobiology (eds) C.C. Pfeiffer and J.R. Smythies, Academic Press, New York.Google Scholar
  11. 11.
    Kan, K.S.K., Chao, L.-P. and Eng, L.F. (1978): Brain. Res. 146: 221–229.PubMedCrossRefGoogle Scholar
  12. 12.
    Kanazawa, I. (1977): Jap. J. Clin. Med. 35: 4025–4029.Google Scholar
  13. 13.
    Kawamura, Y., Dyck, P.J., Shimono, M., Okazaki, H., Tateishi, J. and Doi, H. (1981): J. Neuropathol. Exp. Neurol. 40: 667–675.PubMedCrossRefGoogle Scholar
  14. 14.
    Kimura, H., McGeer, P.L., Peng, J.H. and McGeer, F.G. (1981): J. Comp. Neurol. 200: 151–200.PubMedCrossRefGoogle Scholar
  15. 15.
    Nagata, Y., Oluya, M. and Honda, M. (1981): Neurosci. Lett. Suppl 6: S71.Google Scholar
  16. 16.
    Patten, B.M. and Croft, S. (1984): IN Research Progress in Motor Neurone Disease (ed) F. Clifford Rose, Pitman Press, Bath.Google Scholar
  17. 17.
    Phillis, J.W. (1970): The Pharmacology of Synapsis, Pergamon Press, Oxford, pp 152–160.Google Scholar
  18. 18.
    Scatton, B., Dubois, A., Javoy-Agid, F. and Camus, A. (1984): Neurosci. Lett. 49: 239–245.PubMedCrossRefGoogle Scholar
  19. 19.
    Whitehouse, P.J., Wamsley, J.K., Zarbin, M.A., Price, D.L., Tourtellotte, W.W. and Kuhar, M.J. (1983): Ann. Neurol. 14: 8–16.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • S.-M. Aquilonius
    • 1
  • P.-G. Gillberg
    • 1
  1. 1.Department of Neurology, Akademiska sjukhusetUppsala UniversityUppsalaSweden

Personalised recommendations