Pharmacology of Acetylcholine Activated Ion Channels: Contemporary Approaches

  • Toshio Narahashi


It has long been known that certain guanidine compounds exert complex effects on synaptic and neuromuscular transmission. Guanidine itself increases transmitter release at the neuromuscular and synaptic junctions (Kusano, 1970; Otsuka and Endo, 1960; Teravainen and Larsen, 1975). More recently, the n-alkyl derivatives of guanidine have been found to block ion channels associated with the acetylcholine receptors in the end-plate (Watanabe and Narahashi, 1979).


Conditioning Stimulus Outward Current Squid Axon Open Channel Block Endplate Current 


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Toshio Narahashi
    • 1
  1. 1.Department of PharmacologyNorthwestern University Medical SchoolChicagoUSA

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