Pharmacology of Acetylcholine Activated Ion Channels: Contemporary Approaches
It has long been known that certain guanidine compounds exert complex effects on synaptic and neuromuscular transmission. Guanidine itself increases transmitter release at the neuromuscular and synaptic junctions (Kusano, 1970; Otsuka and Endo, 1960; Teravainen and Larsen, 1975). More recently, the n-alkyl derivatives of guanidine have been found to block ion channels associated with the acetylcholine receptors in the end-plate (Watanabe and Narahashi, 1979).
KeywordsConditioning Stimulus Outward Current Squid Axon Open Channel Block Endplate Current
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