Activation and Blockade of the Nicotinic and Glutamatergic Synapses by Reversible and Irreversible Cholinesterase Inhibitors

  • Edson X. Albuquerque
  • Yasco Aracava
  • Mamdouh Idriss
  • Bernhard Schönenberger
  • Arnold Brossi
  • Sharad S. Deshpande


The nicotinic acetylcholine receptor-ionic channel (AChR)4 of the neuromuscular junction, particularly that from Torpedo electric tissue, is the best characterized of all receptors. It has been functionally isolated, and the topographic arrangement of the polypeptide subunits and the amino acid composition have been detailed (Klymkowsky et al., 1980; Karlin et al., 1983; Noda et al., 1983; Sakmann et al., 1985). The involvement of some of these subunits in the binding sites for drugs has been determined biochemically and electrophysiologically (Krodel et al., 1979; Horn et al., 1980; Karlin, 1980; Aguayo et al., 1981; Spivak and Albuquerque, 1982; Changeux et al., 1984; Wan and Lindstrom, 1984).


Channel Open Time Neuromuscular Synapse Frog Neuromuscular Junction Endplate Current Nicotinic AChR 


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Edson X. Albuquerque
    • 1
  • Yasco Aracava
    • 1
  • Mamdouh Idriss
    • 1
    • 2
  • Bernhard Schönenberger
    • 1
    • 3
  • Arnold Brossi
    • 1
    • 3
  • Sharad S. Deshpande
    • 1
  1. 1.Department of Pharmacology and Experimental TherapeuticsUniversity of Maryland School of MedicineBaltimoreUSA
  2. 2.Division of Entomology, Faculty of AgricultureUniversity of AlexandriaAlexandriaEgypt
  3. 3.Laboratory of ChemistryNational Institute of Diabetes and Digestive and Kidney DiseasesBethesdaUSA

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