Alteration of the Ganglionic Fast EPSC by Anticholinesterase Drugs or Protease Treatment

  • R. L. Parsons
  • D. S. Neel
  • A. B. MacDermott
  • E. A. Connor


Vertebrate autonomic ganglia have proven to be useful model systems for electrophysiological studies of both voltage-dependent and chemically-gated membrane conductances (2, 19). We have used amphibian autonomic ganglia to analyze the basic biophysical and pharmacological properties of nicotinic, cholinergic-gated responses at a vertebrate neuronal synapse (7, 10, 21). Our results have demonstrated that the ganglionic fast excitatory postsynaptic current (EPSC) differs from the more extensively studied muscle end-plate synaptic current (EPC) in its time course, voltage dependence, and response to a number of pharmacological interventions (7–11, 21).


Decay Time Decay Phase Exponential Component Peak Current Amplitude EPSC Amplitude 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • R. L. Parsons
    • 1
  • D. S. Neel
    • 1
  • A. B. MacDermott
    • 2
  • E. A. Connor
    • 3
  1. 1.Dept. of Anatomy & Neurobiology, College of MedicineThe University of VermontBurlingtonUSA
  2. 2.Neurophysiology LabNINCDS-NIHBethesdaUSA
  3. 3.Dept. of NeurobiologyStanford UniversityStanfordUSA

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