Alteration of the Ganglionic Fast EPSC by Anticholinesterase Drugs or Protease Treatment
Vertebrate autonomic ganglia have proven to be useful model systems for electrophysiological studies of both voltage-dependent and chemically-gated membrane conductances (2, 19). We have used amphibian autonomic ganglia to analyze the basic biophysical and pharmacological properties of nicotinic, cholinergic-gated responses at a vertebrate neuronal synapse (7, 10, 21). Our results have demonstrated that the ganglionic fast excitatory postsynaptic current (EPSC) differs from the more extensively studied muscle end-plate synaptic current (EPC) in its time course, voltage dependence, and response to a number of pharmacological interventions (7–11, 21).
KeywordsDecay Time Decay Phase Exponential Component Peak Current Amplitude EPSC Amplitude
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