Presynaptic Modulation of Cortical Acetylcholine Release: Influence of Age and Adenosine
Histochemical and neurochemical investigations demonstrate that the mammalian cerebral cortex contains a diffuse cholinergic network formed prevalently by nerve endings whose somata are located in the basal forebrain nuclei (Mesulam et al., 1983; Wainer et al., 1984). Minor contributions to the cortical cholinergic network are due to a direct projection from the large choline acetyltransferase (ChAT) immunoreactive cells in the pontomesencephalon (Mesulam et al., 1983) and, in the rat, by interneurons scattered throughout all cellular layers in all cortices which contain approximately 30% of total ChAT (Levey et al., 1984; McGeer et al., 1984).
KeywordsCortical Slice Choline Acetyl Transferase Presynaptic Modulation Mammalian Cerebral Cortex Basal Forebrain Nucleus
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