A Pharmacological Study of Acetylcholine Synthesis Storage and Release

  • B. Collier
  • J. Říčný
  • S. A. Welner


The effect of drugs on physiological processes has long been a fruitful way to obtain important information about the neurobiology of acetylcholine (ACh). It seems particularly appropriate to present such an attempt as a contribution to this symposium in recognition of the survival for so many years of Alexander G. Karczmar as the Chairman of his Department of Pharmacology.


Synaptic Vesicle Sympathetic Ganglion Superior Cervical Ganglion Cyclohexene Oxide Cholinergic Nerve Terminal 


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  1. Anderson, D.C., King, S.C., and Parsons, S.M., 1983, Pharmacological charactetization of the acetylcholine transport system in purified Torpedo electric organ synaptic vesicles, Mol. Pharmacol. 24: 48–54.Google Scholar
  2. Barker, L.A., Dowdall, M.J., and Whittaker, V.P., 1972, Choline metabolism in the cerebral cortex of guinea pig, Biochem. J. 130: 1063–1080.Google Scholar
  3. Birks, R.I., and Macintosh, F.C., 1961, Acetylcholine metabolism of a sympathetic ganglion, Can. J. Biochem. Physiol. 39: 787–827.Google Scholar
  4. Blaustein, M.P., 1971, Preganglionic stimulation increases calcium uptake by sympathetic ganglia, Science, 172: 391–393.PubMedCrossRefGoogle Scholar
  5. Brittain, R.T., Levy, G.P., and Tyers, M.B., 1969, The neuromuscular blocking action of 2-(4-phenylpiperidino)cyclohexanol (AH5183), Eur. J. Pharmacol., 8: 93–99.Google Scholar
  6. Collier, B., 1973, The accumulation of hemicholinium by tissues that transport choline, Can. J. Physiol. Pharmacol. 51: 491–495.Google Scholar
  7. Elmqvist, D., and Quastel, D.M.J., 1965, Presynaptic action of hemicholinium at the neuromuscular junction, J. Physiol. ( Lond. ), 177: 463–482.Google Scholar
  8. Israel, M., Dunant, Y., and Manaranche, R., 1979, The present status of the vesicular hypothesis, Prog. Neurobiol., 13:237–2, 75.Google Scholar
  9. Lamarca, M.V., and Collier, B., 1983, Effects of 4-aminopyridine on the cat superior cervical ganglion, J. Pharmacol. Exp. Therap., 226: 249–257.Google Scholar
  10. Large, W.A., and Rang, H.P., 1978, Variability of transmitter quanta released during incorporation of a false transmitter into cholinergic nerve terminals, J. Physiol. ( Lond. ), 285: 25–34.Google Scholar
  11. Macintosh, F.C., and Collier, B., 1976, Neurochemistry of cholinergic terminals, pp. 99–228, in: Neuromuscular Junction, E. Zaimis, ed., Springer-Verlag, Berlin.Google Scholar
  12. Marshall, I.G., 1970a, Studies on the blocking action of 2-(4-phenyl piperidino)cyclohexanol (AH5183), Br. J. Pharmacol., 38: 503–516.Google Scholar
  13. Marshall, I.G., 1970b, A comparison between the blocking actions of 2-(4-phenylpiperidino)cyclohexanol (AH5183) and its N-methyl quaternary analogue (AH5954), Br. J. Pharmacol., 40: 68–77.Google Scholar
  14. Matthews, E.K., 1966, The presynaptic effects of quaternary ammonium compounds on the acetylcholine metabolism of a sympathetic ganglion, Br. J. Pharmacol., 26: 552–566.Google Scholar
  15. Melega, W.P., and Howard, B.D., 1984, Biochemical evidence that vesicles are the source of the acetylcholine released from stimulated PC12 cells, Proc. Nat Acad. Sci. USA, 81: 6535–6538.Google Scholar
  16. Tauc, L., 1982, Nonvesicular release of neurotransmitter. Physiol. Rev., 62: 857–893.Google Scholar
  17. Thesleff, L., 1980, Aminopyridine and synaptic transmission, Neuroscience 5: 1413–1419.PubMedCrossRefGoogle Scholar
  18. Toll, L., and Howard, B.D., 1980, Evidence that an ATPase and a protonmotive force function in the transport of acetylcholine into storage vesicles, J. Biol. Chem. 255: 1787–1789.Google Scholar
  19. Tucek, S., 1984, Problems in the organization and control of acetylcholine synthesis in brain neurons, Prog. Biophys. Molec. Biol., 44: 1–46.Google Scholar
  20. Welner, S.A., and Collier, B., 1984, Uptake, metabolism, and releasability of ethyl analogues of homocholine by rat brain, J. Neurochem., 43: 1143–1151.PubMedCrossRefGoogle Scholar
  21. Zimmermann, H., 1979, Vesicle recycling and transmitter release, Neuroscience, 4: 1773–1804.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • B. Collier
    • 1
  • J. Říčný
    • 1
  • S. A. Welner
    • 1
  1. 1.Department of PharmacologyMcGill UniversityMontrealCanada

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