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AF64A: A Useful Tool in Cholinergic Research

  • Israel Hanin

Abstract

AF64A (ethylcholine aziridinium) has generated considerable interest following the demonstration by Fisher and colleagues, in 1980 (1, 2), that it can induce a persistent central cholinergic hypofunction in vivo. A variety of studies have since been conducted using this compound, in several laboratories, employing a wide array of applications. Neurochemical, electrophysiological, biochemical, morphological and behavioral studies have been completed to date. Data obtained are beginning to provide information regarding the possible mode of action of AF64A, and its selectivity vis-a-vis the cholinergic system in vivo. Findings reported from these studies (excluding the behavioral observations) will be surveyed in this chapter, and our current under-standing of the mode of action of AF64A will be discussed in light of these findings.

Keywords

Cholinergic System Nucleus Basalis ChAT Activity Choline Kinase Choline Transport 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Israel Hanin
    • 1
  1. 1.Western Psychiatric Institute and ClinicUniversity of Pittsburgh School of MedicinePittsburghUSA

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