Synthesis and Biological Evaluation of Fungal Bioregulators of Sterol Biosynthesis

  • Edward J. Parish
  • Patrick K. Hanners
  • W. David Nes


Corey published a leading paper in 196 7 demonstrating that 2, 3-iminosqualene inhibited the cyclization of squalene-oxide to lanosterol in a cell-free system1. In the interim years between then and this seventh international plant lipid symposium, four groups-one each in the United States2, Canada3 another in France4 and Italy4, have firmly established the mechanistic and biological importance of using this and structurally related molecules, e.g. 25-azasteroids5, to interfere with fungal sterol biosynthesis which results in diminished growth response. Industry and biotechnology firms have followed suit in recent years designing analogous inhibitors6, 7 which they believe may have potential promise in plant protection. On the premise that specific N-isopentenoids induce alterations in sterol biosynthesis which in turn may create a pathologic state in the structure and function of membranes of pathogenic fungi, we began a chemical synthesis program in 1984 by preparing blockers targeted at fungal lipid biosynthesis.


Sterol Biosynthesis Ergosterol Biosynthesis Pentacyclic Triterpenoid Biotechnology Firm Analogous Inhibitors6 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Edward J. Parish
    • 1
    • 3
  • Patrick K. Hanners
    • 1
  • W. David Nes
    • 2
  1. 1.Plant and Fungal Lipid Group, Plant Development and Productivity Research Unit, ARSU.S. Department of AgricultureAlbanyUSA
  2. 2.The Plant and Fungal Lipid Group, Plants Physiology Research UnitThe Richard Russell Res. Lab., U.S. Department of AgricultureAthensUSA
  3. 3.Department of ChemistryAuburn UniversityAuburnUSA

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