Inhibition of Growth of Celery Cells by Paclobutrazol and Its Reversal by Added Sterols

  • Penny A. Haughan
  • John R. Lenton
  • L. John Goad

Abstract

Paclobutrazol, (2RS, 3RS)-1-(4-chlorophenyl)-4, 4-dimethyl-2-(1, 2, 4-triazol-1-yl) pentan-3-ol, is a synthetic plant growth retardant 1, 2 which also has a high fungicidal activity.3, 4 The antifungal activity of paclobutrazol is related to its inhibition of sterol biosynthesis4 by interaction with the cytochrome P-450 system required for 14-demethylation of sterol precursors.3, 5 This results in the accumulation of 14 α - methylsterols in fungi.4 Paclobutrazol also exerts plant growth regulatory effects by interfering with gibberellin biosynthesis at the step which is catalysed by the cytochrome P-450 requiring enzyme, kaurene oxidase.2, 3, 6

Keywords

Cholesterol Azole Triazole Gibberellin Ergosterol 

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Penny A. Haughan
    • 1
  • John R. Lenton
    • 2
  • L. John Goad
    • 1
  1. 1.Department of BiochemistryUniversity of LiverpoolLiverpoolUK
  2. 2.Long Ashton Research StationLong Ashton, BristolUK

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