Alterations in Thyroid Function Parameters Following Administration of Fatty Acids

  • Inder J. Chopra
  • Tien-Shang Huang
  • David H. Solomon
  • Guadalupe N. Chua Teco


Recent studies suggest that a thyroid hormone binding inhibitor (THBI) is detected frequently in sera of patients with systemic non-thyroidal illness (NTI) (1–3). There is at present a paucity of information concerning the role of THBI in thyroid hormone abnormalities observed commonly in NTI. THBI appears to be a lipid moiety and unsaturated fatty acids are promising candidate THBIs (1). Serum concentrations of some unsaturated fatty acids (e.g., oleic acid) are markedly increased in NTI (4). In this study, we have examined the effect of the parenteral administration of unsaturated fatty acids on serum thyroid hormone and TSH concentrations in the rat.


Oleic Acid Arachidonic Acid Unsaturated Fatty Acid Serum Thyroid Hormone Dialyzable Fraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Chopra IJ, Huang TS, Hurd RE, et al. J Clin Endocrinol Metab 58: 619, 1983.CrossRefGoogle Scholar
  2. 2.
    Oppenheimer JH, Schwartz HL, Mariash CN, et al. J Clin Endocrinol Metab 54: 757, 1982.PubMedCrossRefGoogle Scholar
  3. 3.
    Chopra IJ, Huang TS, Beredo A, et al. Metabolism (in press).Google Scholar
  4. 4.
    Chopra IJ, Chua Teco GN, Mead JF, et al. J Clin Endocrinol Metab 66: 980, 1985.CrossRefGoogle Scholar
  5. 5.
    Chopra IJ. J Clin Endocrinol Metab 34: 938, 1972.PubMedCrossRefGoogle Scholar
  6. 6.
    Chopra IJ, Ho RS, and Lam R. J Lab Cln Med 80: 729, 1972.Google Scholar
  7. 7.
    Chopra IJ. Metabolism 29: 161, 1980.PubMedCrossRefGoogle Scholar
  8. 8.
    Sterling K and Brenner MA. J Clin Invest 45: 153, 1966.PubMedCrossRefGoogle Scholar
  9. 9.
    Chopra IJ, Van Merle AJ, Chua Teco GN, et al. J Clin Endocrinol Metab 51: 135, 1980.PubMedCrossRefGoogle Scholar
  10. 10.
    Chopra IJ, Solomon DH, Hepner GW, et al. Ann Intern Med 90: 905, 1979PubMedCrossRefGoogle Scholar
  11. 11.
    Chopra IJ, Hershman JM, Pardridge WM, et al. Ann Intern Med 90: 946, 1983.CrossRefGoogle Scholar
  12. 12.
    Wartofsky L and Burnam KD. Endocr Rev 3: 164, 1982.PubMedCrossRefGoogle Scholar
  13. 13.
    Wehmann RE, Gregerman RI, Burns WH, et al. N Engl J Med 312: 546, 1985.PubMedCrossRefGoogle Scholar
  14. 14.
    Bacci V, Schussler GC, and Kaplan TB. J Clin Endocrinol Metab 54: 1229, 1982.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Inder J. Chopra
    • 1
  • Tien-Shang Huang
    • 1
  • David H. Solomon
    • 1
  • Guadalupe N. Chua Teco
    • 1
  1. 1.Department of MedicineUCLA Center for the Health SciencesLos AngelesUSA

Personalised recommendations