Alterations in Thyroid Function Parameters Following Administration of Fatty Acids
Recent studies suggest that a thyroid hormone binding inhibitor (THBI) is detected frequently in sera of patients with systemic non-thyroidal illness (NTI) (1–3). There is at present a paucity of information concerning the role of THBI in thyroid hormone abnormalities observed commonly in NTI. THBI appears to be a lipid moiety and unsaturated fatty acids are promising candidate THBIs (1). Serum concentrations of some unsaturated fatty acids (e.g., oleic acid) are markedly increased in NTI (4). In this study, we have examined the effect of the parenteral administration of unsaturated fatty acids on serum thyroid hormone and TSH concentrations in the rat.
KeywordsOleic Acid Arachidonic Acid Unsaturated Fatty Acid Serum Thyroid Hormone Dialyzable Fraction
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