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Sites of T4 to T3 Conversion in the Rat

  • Jaap van Doorn
  • Daan van der Heide
  • Ferdinand Roelfsema

Abstract

Enzymatic T4 5′-monodeiodination has been demonstrated in a variety of rat tissues (1,2) and may be an important factor in the regulation of T3 concentrations in several target sites of thyroid hormone action. As a consequence, under various (patho)physiological conditions, the total T3 content of tissues which exhibit T4 to T3 conversion in vivo may be affected to an extent not disclosed by alterations in circulating T3 levels. In the present study, we evaluated the relationship between T3 in several extrathyroidal tissues and plasma T3 for both euthyroid and hypothyroid rats.

Keywords

Brown Adipose Tissue Anterior Pituitary Gland Hypothyroid State Thyroid Hormone Action Iopanoic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Kaplan MM. Neuroendocrinology 38: 254, 1984.PubMedCrossRefGoogle Scholar
  2. 2.
    Chopra IJ. Endocrinology 101: 453, 1977.PubMedCrossRefGoogle Scholar
  3. 3.
    van Doorn J, van der Heide D, and Roelfsema F. Endocrinology 115: 705, 1984.PubMedCrossRefGoogle Scholar
  4. 4.
    van Doorn J, van der Heide D, and Roelfsema F. J Clin Invest 72: 1778, 1983.PubMedCrossRefGoogle Scholar
  5. 5.
    van Doorn J, van der Heide D, and Roelfsema F. Endocrinology 115: 174, 1984.PubMedCrossRefGoogle Scholar
  6. 6.
    van Doorn J, Roelfsema F, and van der Heide D. Acta Endocrinol 101: 386, 1982.PubMedGoogle Scholar
  7. 7.
    Larsen PR, Silva JE, and Kaplan MM. Endocr Rev 2: 87, 1981.PubMedCrossRefGoogle Scholar
  8. 8.
    Visser TJ, Kaplan MM, Leonard JL, et al. J Clin Invest 71: 992, 1983.PubMedCrossRefGoogle Scholar
  9. 9.
    Leonard JL, Mellen SA, and Larsen PR. Endocrinology 112: 1153, 1982.CrossRefGoogle Scholar
  10. 10.
    Silva JE, Gordon MB, Crantz FR, et al. J Clin Invest 73: 898, 1984.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Jaap van Doorn
    • 1
  • Daan van der Heide
    • 1
  • Ferdinand Roelfsema
    • 1
  1. 1.Department of EndocrinologyUniversity HospitalLeidenThe Netherlands

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