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Effect of Dilution on FT3 and FT4 Concentration in Serum Containing Substances That Interact with Thyroid Hormone-Binding Proteins

  • Niels Boye
  • Hans Orskov
  • Jorgen Weeke

Abstract

Almost all available methods for FT3 and FT4 determination include a dilution step of serum. Even in the direct determination using dialysis, a method that has been regarded as a reference technique, dilution is unavoidable. The effect of dilution will be more pronounced on an interacting but weakly bound substance than on the binding of thyroid hormones to the transport proteins. This means that, in serum that contains such compounds, the free concentration of thyroid hormones will be underestimated, if dilution is employed.

Keywords

Thyroid Hormone Equilibrium Dialysis Dialysis Tube Free Thyroid Hormone Thyroid Hormone Status 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Weeke J and Orskov H. In KGMM Alberti (ed), Recent Advances in Clinical Biochemistry, Churchill Livingstone, Edinburgh, 1978, p 111.Google Scholar
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    Stockigt JR, Stevens V, White EL, et al. Clin Chem 29: 1408, 1983.PubMedGoogle Scholar
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    Taylor R, Huttong C, and Weeke J. Clin Endocrinol (Oxf) 19: 683, 1983.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Niels Boye
    • 1
  • Hans Orskov
    • 1
  • Jorgen Weeke
    • 1
  1. 1.Second University Clinic of Internal MedicineKommunehospitaletAarhus CDenmark

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