Role of the Pituitary Iodothyronine 5’Deiodinase Activity in the Negative Feedback by Thyroid Hormone upon TSH Release

  • J. Enrique Silva


It is widely accepted that triiodothyronine (T3) accounts for nearly all of the thyromimetic potency of thyroidal secretion. The nuclear thyroid hormone receptors bind T3 with > 10-fold higher affinity than thyroxine (T4), and the intracellular concentration of T4 is not enough to occupy more than 10f of these receptors—a substantial fraction of which may actually be non-specifically bound. About a decade ago, this and the relatively rapid exchange of plasma T3 with the receptor, led to the concept that the thyroid status of the tissues was closely reflected by the plasma concentration of T3 (1).


Thyroid Hormone Iodine Deficiency Iopanoic Acid Pituitary Homogenate Nuclear Thyroid Hormone Receptor 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • J. Enrique Silva
    • 1
  1. 1.Howard Hughes Medical Institute Laboratory, Brigham and Womens’ Hospital, Department of MedicineHarvard Medical SchoolBostonUSA

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