Effect of Long-Chain Fatty Acids on the Binding of T4 and T3 to Human Thyroxine-Binding Globulin (TBG)

  • Milton Tabachnick
  • Ladislav Korcek


Long-chain free fatty acids (FFA) such as oleic and linoleic acids have been shown to inhibit the binding of T4 to binding proteins in serum (1–3). In a recent report, Chopra and coworkers (4) have presented evidence indicating tht circulating FFA, especially oleic acid, makes an important contribution to thyroid hormone binding inhibitor (THBI) activity found in sera of certain patients with nonthyroidal illnesses (NTI). Although oleic acid and linoleic acid are known to inhibit T4 binding to albumin (5), the effect of FFA on T4 binding to TBG, the major thyroid hormone-binding protein in serum, has not been studied directly. In the present study, we compared the effect of different FFA on the binding of T4 to pure TBG.


Free Fatty Acid Oleic Acid Free Fatty Acid Level Scatchard Plot Nonthyroidal Illness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Hollander CS, Scott RL, Burgess JA, et al. J Clin Endocrinol Metab 27: 1219, 1967.PubMedCrossRefGoogle Scholar
  2. 2.
    Tabachnick M, Hao YL, and Korcek L. J Clin Endocrinol Metab 36: 392, 1973.PubMedCrossRefGoogle Scholar
  3. 3.
    Chopra IJ, Huang TS, Hurd RE, et al. J Clin Endocrinol Metab 58: 619, 1984.PubMedCrossRefGoogle Scholar
  4. 4.
    Chopra IJ, Teco GNC, Mead JF, et al. J Clin Endocrinol Metab 60: 980, 1985.PubMedCrossRefGoogle Scholar
  5. 5.
    Tabachnick M. Arch Biochem Biophys 106: 415, 1964.PubMedCrossRefGoogle Scholar
  6. 6.
    Korcek L and Tabachnick M. J Biol Chem 251: 3558, 1976.PubMedGoogle Scholar
  7. 7.
    Goodman DW. J Am Chem Soc 80: 3887, 1958.CrossRefGoogle Scholar
  8. 8.
    Siegel JS, Korcek L, and Tabachnick M. Endocrinology 113: 2173, 1983.PubMedCrossRefGoogle Scholar
  9. 9.
    Scatchard G. Ann NY Acad Sci 51: 660, 1959.CrossRefGoogle Scholar
  10. 10.
    Dole VP. J Clin Invest 35: 150, 1955.CrossRefGoogle Scholar
  11. 11.
    Korcek L and Tabachnick M. Biochim Biophys Acta 371: 323, 1974.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Milton Tabachnick
    • 1
  • Ladislav Korcek
    • 1
  1. 1.Department of BiochemistryNew York Medical CollegeValhallaUSA

Personalised recommendations