Preferential Metabolism of T4 to rT3 (T3 Reverse) in Hyperthyroxinemia Induced by L-Thyroxine (L-T4) Treatment of Hypothyroidism in Children and Adolescents

  • Sonia Iorcansky
  • Marco A. Rivarola


Preferential conversion to rT3, an inert metabolite of T4, has been proposed as a homeostatic mechanism for thyroid hormone inactivation in several physiopathological situations (1,2).


Homeostatic Mechanism Hypothyroid Patient Inhibitory Dose Neonatal Thyroid Preferential Metabolism 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Chopra IJ. J Clin Invest 54: 583, 1974.PubMedCrossRefGoogle Scholar
  2. 2.
    Wartofsky L and Burman KD. Endocrine Rev 3: 164, 1982.CrossRefGoogle Scholar
  3. 3.
    Visser TJ, Leonard JL, Kaplan MM, et al. Proc Natl Acad Sci USA 79: 5080, 1982.PubMedCrossRefGoogle Scholar
  4. 4.
    Guyda HJ. In GN Burrow and JH Dussault (eds), Neonatal Thyroid Screening, Raven Press, New York, 1980, p 247.Google Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Sonia Iorcansky
    • 1
  • Marco A. Rivarola
    • 1
  1. 1.Centro de Investigaciones Endocrinologicas, Division de EndocrinologiaHospital de Ninos “Dr. Ricardo Gutierrez”Buenos AiresArgentina

Personalised recommendations