Extrathyroidal Conversion of Thyroxine To 3,5,3’-Triiodothyronine in Rats Undergoing Acute Immobilization Stress
Several experimental and clinical conditions sharing stress as a common factor (i.e., fasting, surgical procedures, severe non-thyroidal systemic illnesses) are known to induce marked alterations on the extrathyroidal metabolism of iodothyronines (1). These alterations, known as the “low T3 syndrome,” are characterized by low 3,5,3’–triiodothyronine (T3), and high 3,3’,5’–triiodothyronine (rT3) serum concentrations, while thyroxine (T4) values in serum may be decreased or unchanged (2).
KeywordsImmobilization Dexamethasone Glucocorticoid Corticosterone Thyroxine
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