Extrathyroidal Conversion of Thyroxine To 3,5,3’-Triiodothyronine in Rats Undergoing Acute Immobilization Stress
Several experimental and clinical conditions sharing stress as a common factor (i.e., fasting, surgical procedures, severe non-thyroidal systemic illnesses) are known to induce marked alterations on the extrathyroidal metabolism of iodothyronines (1). These alterations, known as the “low T3 syndrome,” are characterized by low 3,5,3’–triiodothyronine (T3), and high 3,3’,5’–triiodothyronine (rT3) serum concentrations, while thyroxine (T4) values in serum may be decreased or unchanged (2).
KeywordsThyroid Hormone Bilateral Adrenalectomy Marked Alteration Kidney Homogenate Immobilization Period
Unable to display preview. Download preview PDF.
- 3.Russo EMK, Vieira JGH, Maciel RMB, et al. Arq Bras Endocrinol Metab 26: 23, 1982.Google Scholar