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Chromatographic Properties and Probable Structure of the Urinary Conjugate of an Ethane-1,2-Diol Formed in Vivo from 3,5,3’-Triiodothyronine (T3)

  • Janice T. Gordon
  • Mary B. Dratman
  • Alfred L. Yergey

Abstract

In earlier communications we have suggested that the diverse actions of thyroid hormones could be explained in one coherent framework if thyroxine were viewed as an amino acid (1,2). Both thyroxine (T4) and its mono-deiodination product, 3,5,3’-triiodothyronine (T3), are aromatic amino acids not only derived from, but similar in structure to tyrosine. In view of the adrenergic effects of thyroid hormones, it seemed reasonable to propose that T4, like tyrosine, would be taken into the nervous system where it and its metabolites could become substrates for the same enzymes which take part in the transformation of tyrosine to the adrenergic neurotransmitters, as well as to their major catabolic products.

Keywords

Thyroid Hormone Aromatic Amino Acid Aryl Sulfatase Adrenergic Effect Adrenergic Neurotransmitter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Dratman MB. J Theoret Biol 46: 255, 1974.CrossRefGoogle Scholar
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    Dratman MB. In CH Li (ed), Hormonal Proteins and Peptides, Academic Press, New York 1978, p 205.Google Scholar
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    Dratman MB, Futaesaku Y, Crutchfield FL, et al. Science 215: 309, 1982.PubMedCrossRefGoogle Scholar
  4. 4.
    Dratman MB, Crutchfield FL, Futaesaku Y, et al. Submitted to Neuroscience.Google Scholar
  5. 5.
    Gordon JT, Dratman MB, and Wassel MS. Abstract #847, 67th Annual Meeting of the Endocrine Society, 1985.Google Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Janice T. Gordon
    • 1
    • 2
  • Mary B. Dratman
    • 1
    • 2
  • Alfred L. Yergey
    • 1
    • 2
  1. 1.VA Medical Center and Medical College of PennsylvaniaPhiladelphiaUSA
  2. 2.National Institutes of HealthBethesdaUSA

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