Chromatographic Properties and Probable Structure of the Urinary Conjugate of an Ethane-1,2-Diol Formed in Vivo from 3,5,3’-Triiodothyronine (T3)
In earlier communications we have suggested that the diverse actions of thyroid hormones could be explained in one coherent framework if thyroxine were viewed as an amino acid (1,2). Both thyroxine (T4) and its mono-deiodination product, 3,5,3’-triiodothyronine (T3), are aromatic amino acids not only derived from, but similar in structure to tyrosine. In view of the adrenergic effects of thyroid hormones, it seemed reasonable to propose that T4, like tyrosine, would be taken into the nervous system where it and its metabolites could become substrates for the same enzymes which take part in the transformation of tyrosine to the adrenergic neurotransmitters, as well as to their major catabolic products.
KeywordsThyroid Hormone Aromatic Amino Acid Aryl Sulfatase Adrenergic Effect Adrenergic Neurotransmitter
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