Regulation of HLA-DR Gene Expression in Cultured Human Thyroid Cells: A Role for Lectin, Gamma Interferon, and Cyclosporine
HLA Class II antigens (DR, DQ, and DP) are expressed primarily on the surface of the lymphocytes (B and activated T cells) and cells of the monocyte-macrophage lineage, but may also be expressed in a variety of tissues, in particular those which contain immune infiltration with local release of lymphokines (i.e., gamma interferon), which are potent inducers of Class II antigen expression. Immunofluorescence studies have demonstrated that although normal human thyroid tissue is negative for DR antigen, HLA-DR antigen is present in human thyroid cells in cases of autoimmune thyroid disease such as Graves’ hyperthyroidism (1,2). Furthermore, Class II HLA-DR antigen in normal thyroid cells is detected after exposure in vitro to lectin or gamma-interferon (1,3). Since Class II antigens are important in T cell amplification, antigen presentation and self-recognition (4), such quantitative differences in DR antigen expression in the thyroid may be involved in the control of thyroid autoimmunity. In order to further elucidate the role of Class II antigens in thyroid immunoregulation, we have studied HLA-DR antigen gene expression in a variety of cultured human thyroid cells.
KeywordsThyroid Cell Human Thyroid Autoimmune Thyroid Disease Slot Blot Human Thyroid Cell
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