Effect of TSH and Thyroid-Stimulating Antibody (TSAb) on the Desensitization of the Adenylate Cyclase Activity in FRTL-5 Cells
Thyroid-stimulating hormone (TSH) is known to stimulate the thyroid adenylate cyclase-cAMP system (1). Hormonal stimulation of adenylate cyclase produces an immediate response followed by a reduced responsiveness to a subsequent challenge with the hormone itself. This phenomenon is referred to as desensitization of refractoriness and is believed to be dependent on new protein synthesis (2,3). Furthermore, iodide in the thyroid gland, independently from TSH, can modulate thyroid function by inhibiting several metabolic steps (4). Thus, thyroid function is regulated in a complex manner, where pituitary and autoregulatory mechanisms can be distinguished.
KeywordsAdenylate Cyclase Thyroid Cell Acute Stimulation Preincubation Period Thyroid Cell Line
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