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Hormonal Regulation of DNA Polymerase ß Activity in Rat Thyroid Gland

  • Takako Ohyama
  • Akio Nagasaka
  • Shonen Yoshida
  • Akira Nakai
  • Katsumi Iwase
  • Susumu Ohtani
  • Hifumi Nakagawa
  • Rumi Musunaga
  • Sumio Kato
  • Kunitaka Kataoka

Abstract

Our previous studies provided the evidence that rat adrenal gland and testis contain three species of DNA polymerase, α, ß, and γ (1,2). Among them, the ß-enzyme activity in the endocrine organs was modulated by pituitary trophic hormones. Namely, the manipulation of hypophysectomy reduced the level of ß-enzyme activity and changed its molecular size. These changes were reversed by the administration of the pituitary trophic hormone to the hypophysectomized rat. Therefore, DNA polymerase ß activity may be strongly regulated by the feedback mechanism in these endocrine organs. Here we extended our work to another endocrine organ, the thyroid gland, which is regulated by TSH and shows some extent of autoregulation under the depletion of TSH.

Keywords

Thyroid Gland Endocrine Organ Molecular Weight Form Sucrose Gradient Centrifugation High Molecular Weight Form 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Nagasaka A and Yoshida S. Endocrinology 111: 1345, 1982.PubMedCrossRefGoogle Scholar
  2. 2.
    Nagasaka A and Yoshida S. Endocrinology 115: 1110, 1984.PubMedCrossRefGoogle Scholar
  3. 3.
    Weissbach A. Annu Rev Biochem 46: 25, 1977.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Takako Ohyama
  • Akio Nagasaka
  • Shonen Yoshida
    • 1
  • Akira Nakai
  • Katsumi Iwase
    • 2
  • Susumu Ohtani
    • 2
  • Hifumi Nakagawa
  • Rumi Musunaga
  • Sumio Kato
  • Kunitaka Kataoka
  1. 1.Institute for Disease Mechanism and ControlNagoya University School of MedicineShowa-kuJapan
  2. 2.Department of Internal Medicine and SurgeryFujita-Gakuen Health University School of MedicineToyoakeJapan

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