Formation of Intracytoplasmic Microfollicular Lumina in Dispersed Thyroid Cells
Dispersed thyroid cells have been used as a convenient experimental system to study thyroid cell activities in the absence of normal tissue architecture and colloid stores. Iodination inside the cells was demonstrated to be dependent on active iodide transport and regulated by thyrotropin (1,2). Electron microscopic autoradiographic studies revealed intracytoplasmic lumina (ICL) which represent a site of iodination inside dispersed thyroid cells (3). The aim of the present work was to answer the following questions: a) which are the conditions determining the formation of ICL? and b) do thyroid hormone synthesis and secretion by dispersed thyroid cells depend upon iodination reactions in ICL?
KeywordsThyroid Cell Thyroid Hormone Synthesis Organic Iodine Colloid Droplet Iodination Reaction
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