The Effect of Epidermal Growth Factor (EGF) on Thyroid Function in the Sheep and in Isolated Rat Hepatocytes
Evidence has accumulated in recent years showing that EGF is mitogenic in cultured thyroid cells while inhibiting 125I uptake, transport, and organification (1–6). In thyroid follicles, EGF has specific receptors with Ka 1.2 x 10−9 M and capacity of 7.9 pmol/g tissue (1). The aim of this study was to extend previous investigations (1,2,7), describing in vivo of EGF on thyroid function and to investigate the effects of EGF of peripheral metabolism of thyroid hormones in isolated hepatocytes.
KeywordsEpidermal Growth Factor Thyroid Follicle Crude Homogenate Deiodinase Activity Basal Medium Eagle
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- 1.Waters MJ, Whip TA, McGrath P, et al. Proc Endocr Soc Aus 26: 39, 1983.Google Scholar
- 2.Waters MJ, Corcoran JM, Tennison M, et al. Proc Endocr Soc Aus 25: 34, 1982.Google Scholar
- 7.Corcoran JM, Waters MJ, Jorgensen G, et al. (submitted to Endo-crinol.).Google Scholar
- 8.Cohen S and Savage Jr CR. Meth Enzymol 36: 424, 1974.Google Scholar
- 10.Cutten AE, Smith HC, Corcoran JM, et al. (in preparation)Google Scholar