Advertisement

The Effect of Epidermal Growth Factor (EGF) on Thyroid Function in the Sheep and in Isolated Rat Hepatocytes

  • Jo M. Corcoran
  • Michael J. Waters
  • Jonathan Marks
  • Greg Jorgensen
  • Kay V. Waite
  • Creswell J. Eastman

Abstract

Evidence has accumulated in recent years showing that EGF is mitogenic in cultured thyroid cells while inhibiting 125I uptake, transport, and organification (1–6). In thyroid follicles, EGF has specific receptors with Ka 1.2 x 10−9 M and capacity of 7.9 pmol/g tissue (1). The aim of this study was to extend previous investigations (1,2,7), describing in vivo of EGF on thyroid function and to investigate the effects of EGF of peripheral metabolism of thyroid hormones in isolated hepatocytes.

Keywords

Epidermal Growth Factor Thyroid Follicle Crude Homogenate Deiodinase Activity Basal Medium Eagle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Waters MJ, Whip TA, McGrath P, et al. Proc Endocr Soc Aus 26: 39, 1983.Google Scholar
  2. 2.
    Waters MJ, Corcoran JM, Tennison M, et al. Proc Endocr Soc Aus 25: 34, 1982.Google Scholar
  3. 3.
    Roger RP and Dumont JE. FEBS Lett 144 (2): 209, 1982.PubMedCrossRefGoogle Scholar
  4. 4.
    Westermark K and Westermark B. Exp Cel1 Res 138: 47, 1982.CrossRefGoogle Scholar
  5. 5.
    Karlsson FA, Westermark K, and Westermark B. Mol Cell Endocr 28: 99, 1982.CrossRefGoogle Scholar
  6. 6.
    Humphries H, MacNiel S, Munro DS, et al. J Endocr 102: 57, 1984.PubMedCrossRefGoogle Scholar
  7. 7.
    Corcoran JM, Waters MJ, Jorgensen G, et al. (submitted to Endo-crinol.).Google Scholar
  8. 8.
    Cohen S and Savage Jr CR. Meth Enzymol 36: 424, 1974.Google Scholar
  9. 9.
    Berry MN and Friend DS. J Cell Biol 43: 506, 1969.PubMedCrossRefGoogle Scholar
  10. 10.
    Cutten AE, Smith HC, Corcoran JM, et al. (in preparation)Google Scholar
  11. 11.
    Dussault JH, Hobel CJ, and Fisher DA. Endocr 88: 47, 1971.CrossRefGoogle Scholar
  12. 12.
    Dussault JH, Hobel CJ, DiStefano JJ, et al. Endocr 90: 1301, 1972.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Jo M. Corcoran
    • 1
  • Michael J. Waters
    • 2
  • Jonathan Marks
    • 1
  • Greg Jorgensen
    • 2
  • Kay V. Waite
    • 1
  • Creswell J. Eastman
    • 1
  1. 1.Department of MedicineWestmead CentreAustralia
  2. 2.Department of Physiology and PharmacologyUniversity of QueenslandAustralia

Personalised recommendations