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Growth Factor Requirement of Isolated Thyroid Follicles

  • Philip Smith
  • David Wynford-Thomas
  • E. Dillwyn Williams

Abstract

Our previous studies in intact animals (1,2) have demonstrated the existence of a growth desensitization mechanism which limits the proliferative response of the normal rat thyroid follicular cell to its trophic hormone, TSH, and which appears to be lost in early follicular cell tumors. To study this mechanism further we have established a tissue culture model using isolated thyroid follicles grown in suspension. We have now used this to define the responsiveness of normal follicular cells to purified growth factors in a serum-free medium.

Keywords

Label Index Follicular Cell Growth Factor Requirement Tissue Culture Model Trophic Hormone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Wynford-Thomas D, Stringer BMJ, and Williams ED. Acta Endocrinol 101, 21, 1982.Google Scholar
  2. 2.
    Wynford-Thomas D, Stringer BMJ, and Williams ED. Virch Archiv (Cell Pathol) 40: 379, 1982.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Philip Smith
    • 1
  • David Wynford-Thomas
    • 1
  • E. Dillwyn Williams
    • 1
  1. 1.Department of PathologyUniversity of Wales College of MedicineCardiff, WalesUK

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