Effect of Calmodulin Inhibitors on Thyroid Hormone Secretion
It is well known that the intracellular free Ca2+ plays a role in TSHinduced thyroid hormone secretion (1). Onaya et al. have reported that chlorpromazine inhibits TSH-stimulated endocytosis and glucose oxidation in canine thyroid slices (2). Chlorpromazine inhibits the action of calmodulin which is contained in the thyroid and may act on tubulin assembly-disassembly (3). These findings led us to postulate that calmodulin plays a role in TSH-induced thyroid hormone secretion.
KeywordsMyosin Light Chain Kinase Thyroid Lobe Calmodulin Inhibitor Thyroid Hormone Secretion Thyroid Hormone Release
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