Advertisement

Effect of Calmodulin Inhibitors on Thyroid Hormone Secretion

  • Akira Nakai
  • Akio Nagasaka
  • Takako Ohyama
  • Toshihiro Aono
  • Rumi Masunaga
  • Hifumi Nakagawa
  • Kunitaka Kataoka
  • Katsumi Iwase
  • Susumu Ohtani
  • Hiroyoshi Hidaka
  • Toshio Tanaka

Abstract

It is well known that the intracellular free Ca2+ plays a role in TSHinduced thyroid hormone secretion (1). Onaya et al. have reported that chlorpromazine inhibits TSH-stimulated endocytosis and glucose oxidation in canine thyroid slices (2). Chlorpromazine inhibits the action of calmodulin which is contained in the thyroid and may act on tubulin assembly-disassembly (3). These findings led us to postulate that calmodulin plays a role in TSH-induced thyroid hormone secretion.

Keywords

Myosin Light Chain Kinase Thyroid Lobe Calmodulin Inhibitor Thyroid Hormone Secretion Thyroid Hormone Release 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Zor U, Lowe IP, Bloon G, et al. Biochem Biophys Res Commun 33: 64, 1968CrossRefGoogle Scholar
  2. 2.
    Onaya T, Solomon DH, and Davidson WD. Endocrinology 85: 150, 1969.PubMedCrossRefGoogle Scholar
  3. 3.
    Marcum JM, Dedman JR, Brinkley BR, et al. Proc Natl Acad Sci 75: 3771, 1978.PubMedCrossRefGoogle Scholar
  4. 4.
    Visser TJ, Van Der Does-Tobe I, Docter R, et al. Biochem J 150: 489, 1975.Google Scholar
  5. 5.
    Ollis CA, Davier R, Munro DS, et al. Bioscience Reports 4: 695, 1984.PubMedCrossRefGoogle Scholar
  6. 6.
    Kubota N, Mitsuhashi T, Kuzuya N, et al. Folia Endocrinologica Japonica 59: 641, 1983 (abstract).Google Scholar
  7. 7.
    Valverde I, Vandermeers A, Anjaneyulu R, et al. Science 206: 225, 1979.PubMedCrossRefGoogle Scholar
  8. 8.
    Le Donne NC and Coffe CJ. Ann NY Acad Sci 356: 402, 1980.CrossRefGoogle Scholar
  9. 9.
    Hidaka H, Naka M, and Yamaki T. Biochem Biophys Res Commun 90: 694, 1979.PubMedCrossRefGoogle Scholar
  10. 10.
    Onaya T, Takazawa K, and Shibata K. Acta Endocrinologica Japonica (in press).Google Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Akira Nakai
    • 1
  • Akio Nagasaka
    • 1
  • Takako Ohyama
    • 1
  • Toshihiro Aono
    • 1
  • Rumi Masunaga
    • 1
  • Hifumi Nakagawa
    • 1
  • Kunitaka Kataoka
    • 1
  • Katsumi Iwase
    • 2
  • Susumu Ohtani
    • 2
  • Hiroyoshi Hidaka
    • 3
  • Toshio Tanaka
    • 3
  1. 1.Department of Internal Medicine MedicineFujita-Gakuen Health University School of MedicineToyoake, AichiJapan
  2. 2.Department of SurgeryFujita-Gakuen Health University School of MedicineToyoake, AichiJapan
  3. 3.Department of PharmacologyMie University School of MedicineTsu, MieJapan

Personalised recommendations