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Acute in Vitro Stimulatory Effect of Thyrotropin Releasing Hormone (TRH) on T4 Secretion in Rat and Human Thyroid

  • Paul Valensi
  • Jean-Raymond Attali
  • Dorian Darnis
  • Jacques Sebaoun

Abstract

TRH distribution is ubiquitous. In addition to the hypothalamus, TRH has been found in different parts of the brain, the islets of Langerhans, the testis, the placenta, and amniotic fluid (1). Evidence of TRH immunoreactivity has also been found in the porcine and human thyroid gland (2). Rat thyroid concentrates the injected labeled TRH (3). These findings suggest that TRH may have a direct effect on the thyroid gland. Prolonged intermittent or continuous infusion of TRH in rhesus monkeys at first induced a rise in TSH and T4, but while TSH went down to its basal value by the third day, T4 increased up to the ninth day (4). Similar results were reported in fasting humans (5). The late TSH decrease could result from the negative feedback of T4, but the fact that T4 continued to rise while TSH decreased suggests a stimulatory effect of TRH on T4 secretion.

Keywords

Thyrotropin Release Hormone Human Thyroid Kinetic Pattern Adenylate Cyclase System Human Thyroid Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Paul Valensi
    • 1
  • Jean-Raymond Attali
    • 1
  • Dorian Darnis
    • 1
  • Jacques Sebaoun
    • 1
  1. 1.Laboratoire d’Endocrinologie Clinique et MetaboliqueHopital Avicenne, U.E.R. Paris NordBobignyFrance

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