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Effects of Phorbol Esters on Protein Phosphorylation and Free T3 Release by Mouse Thyroid Lobes

  • Kazutaka Haraguchi
  • Toyoshi Endo
  • Toshimsa Onaya

Abstract

Phospholipid-dependent calcium-activated protein kinase, previously identified and termed protein kinase C (1), is known to be widely distributed among various tissues. Although many proteins can be substrates of protein kinase C, little is known about its physiological role. Diacylglycerol, a major degradative product of phosphatidylinositol (PI) turnover, was reported to stimulate protein kinase C in vitro (2). Previously, Igarashi and Kondo (3) have clearly shown that a transient increase of diacylglcerol is elicited by TSH in hog thyroid follicles. We, therefore, wished to know whether thyroid protein kinase C has a role in thyroid physiology. In the present paper, we report some aspects of protein kinase C in mouse thyroid lobes.

Keywords

PHORBOL Ester Thyroid Hormone Secretion Stimulate Protein Kinase Bind Protein Kinase Yamanashi Medical 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Kazutaka Haraguchi
    • 1
  • Toyoshi Endo
    • 1
  • Toshimsa Onaya
    • 1
  1. 1.The Third Department of Internal MedicineUniversity of Yamanashi Medical SchoolTamaho, Yamanashi-kenJapan

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