Effects of Phorbol Esters on Protein Phosphorylation and Free T3 Release by Mouse Thyroid Lobes
Phospholipid-dependent calcium-activated protein kinase, previously identified and termed protein kinase C (1), is known to be widely distributed among various tissues. Although many proteins can be substrates of protein kinase C, little is known about its physiological role. Diacylglycerol, a major degradative product of phosphatidylinositol (PI) turnover, was reported to stimulate protein kinase C in vitro (2). Previously, Igarashi and Kondo (3) have clearly shown that a transient increase of diacylglcerol is elicited by TSH in hog thyroid follicles. We, therefore, wished to know whether thyroid protein kinase C has a role in thyroid physiology. In the present paper, we report some aspects of protein kinase C in mouse thyroid lobes.
KeywordsPHORBOL Ester Thyroid Hormone Secretion Stimulate Protein Kinase Bind Protein Kinase Yamanashi Medical
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- 2.Kishimoto A, Takai Y, More T, et al. J Biol Chem 255: 2273, 1973.Google Scholar