Short-Term in Vitro Stimulatory Effect of Glucagon on T4 Secretion in Rat and Human Thyroid

  • Jean-Raymond Attali
  • Paul Valensi
  • Dorian Darnis
  • Claude Weisselberg
  • Jacques Sebaoun


Although hyperthyroidism is rarely associated with diabetes mellitus (1), it is often complicated by impairment of glucose tolerance (2). High concentrations of plasma glucagon are often found in hyperthyroidism (3). In poorly controlled diabetes mellitus, as in other acute episodes of severe diseases, the plasma T3 level is reduced, whereas the plasma reverse T3 level is elevated (1). Hyperglucagonemia, often found in such catabolic states (4,5), does not seem to be involved in this reduction of the plasma T3 level (6). Furthermore, glucagon reduces the number of T3 nuclear receptors in rat hepatocytes (7), and the thyroid hormones modify the plasma cyclic AMP response to glucagon (8).


Human Thyroid Stimulation Period Kinetic Pattern Glucagon Concentration Control Diabetes Mellitus 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Jean-Raymond Attali
    • 1
  • Paul Valensi
    • 1
  • Dorian Darnis
    • 1
  • Claude Weisselberg
    • 1
  • Jacques Sebaoun
    • 1
  1. 1.Laboratoire d’Endocrinologie Clinique et MetaboliqueHopital AvicenneBobignyFrance

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