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Dopamine and L-Dopa, Precursors of Norepinephrine: Effects on Thyroxine Release

  • M. L. Maayan
  • E. M. Volpert
  • R. V. Sellitto

Abstract

Norepinephrine (NE), epinephrine, and their precorsors have been shown to enhance iodide organification in calf thyroid tissue through alpha-adrenergic receptors (1). In an in vitro mouse thyroid preparation, NE concomitantly stimulated iodide organification and inhibited thyrotropin (TSH)stimulated thyroxine (T4) release (2,3). Recently such inhibition of TSHstimulated T4 release was confirmed in vivo (4). In the present study, dopamine (DA) and L-DOPA also inhibited TSH-stimulated T4 release through alpha-adrenergic and dopaminergic receptors; cAMP appeared to be an unlikely mediator.

Keywords

Thyroid Lobe Dopaminergic Receptor Acid Decarboxyl Thyroidal Iodine Iodide Organification 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Maayan ML, Shapiro R, and Ingbar SH. Endocrinology 92: 912, 1973.PubMedCrossRefGoogle Scholar
  2. 2.
    Maayan ML, Debons AF, Krimsky I, et al. Endocrinology 101: 284, 1981.CrossRefGoogle Scholar
  3. 3.
    Maayan ML, Volpert EM, and From A. Endocrinology 109: 930, 1981.PubMedCrossRefGoogle Scholar
  4. 4.
    Ahren B. Acta Endocrinol 108: 184, 1985.PubMedGoogle Scholar
  5. 5.
    Krulick L, Mayfield MA, Steele MK, et al. Endocrinology 110: 796, 1981.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • M. L. Maayan
    • 1
    • 2
  • E. M. Volpert
    • 1
    • 2
  • R. V. Sellitto
    • 1
    • 2
  1. 1.Veterans Administration Medical CenterBrooklynUSA
  2. 2.SUNY Downstate Medical CenterBrooklynUSA

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