Ontogeny of Human Pancreatic Thyrotropin-Releasing Hormone

  • Giovanni Bambini
  • Enio Martino
  • Sebastiano Grasso
  • Giuseppe Pardo
  • Fabrizio Aghini-Lombardi


It is known that thyrotropin-releasing hormone (TRH) is present in hypothalami, as well as in other cerebral areas and in other tissues including the gastrointestinal tract and, particularly, the pancreas (1–7). In rats, the islets of Langerhans are the main source of pancreatic TRH (6) and it has been shown immunohistochemically that TRH is localized especially in marginal islet cells (8,9). The role of pancreatic TRH is not well established (10), but it has been shown to enhance arginine-induced glucagon release in the adult dog (11). Ontogenetic studies in rats have demonstrated that pancreatic TRH content is higher in the neonatal period and progressively declines after the first weeks of life (5,12–14). No data are available on the ontogeny of pancreatic TRH in humans and this represents the aim of the present study.


Insulin Content Cerebral Area Early Neonatal Period Fetal Pancreas Ontogenetic Study 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Giovanni Bambini
    • 1
  • Enio Martino
    • 1
  • Sebastiano Grasso
    • 2
  • Giuseppe Pardo
    • 2
  • Fabrizio Aghini-Lombardi
    • 1
  1. 1.Cattedra di Endocrinologia e Medicina CotituzionaleUniversity of PisaPisaItaly
  2. 2.Istituto di Anatomia PatologicaUniversita di CataniaCataniaItaly

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