Measurements of Thyrotropin-Releasing Hormone (TRH)-Like Immunoreactivity in Human Blood in Thyroid Diseases
Human blood TRH-like immunoreactivity levels were estimated by a new, highly specific and sensitive RIA in various abnormal thyroid states. Blood samples were extracted by cold methanol. All results were expressed in fmoles/ml (mean ± SD).
The TRH-like immunoreactivity levels were 44.5 ± 5.2 in 9 normal adult subjects and 50.4 ± 4.1 in 6 euthyroid subjects with simple goiter. Blood TRH-like immunoreactivity was found significantly increased in 19 patients with M. Basedow or with autonomy (132 ± 33; p<0.01), and significantly decreased in 12 hypothyroid patients (21 ± 3; p<0.01). These findings suggest that peripheral thyroid hormones may be involved in the T4-TRH regulation mechanism and the hypothesis of a possible positive feedback of T4 at hypothalamic level can, thus, be confirmed.
KeywordsThyroid Disease Cold Methanol Hypothyroid Patient Hyperthyroid Patient Hypothalamic Level
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