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Measurements of Thyrotropin-Releasing Hormone (TRH)-Like Immunoreactivity in Human Blood in Thyroid Diseases

  • Leonidas Duntas
  • Dominique Grouselle
  • Fritz S. Keck
  • Ulrich Loos
  • Ernst F. Pfeiffer

Summary

Human blood TRH-like immunoreactivity levels were estimated by a new, highly specific and sensitive RIA in various abnormal thyroid states. Blood samples were extracted by cold methanol. All results were expressed in fmoles/ml (mean ± SD).

The TRH-like immunoreactivity levels were 44.5 ± 5.2 in 9 normal adult subjects and 50.4 ± 4.1 in 6 euthyroid subjects with simple goiter. Blood TRH-like immunoreactivity was found significantly increased in 19 patients with M. Basedow or with autonomy (132 ± 33; p<0.01), and significantly decreased in 12 hypothyroid patients (21 ± 3; p<0.01). These findings suggest that peripheral thyroid hormones may be involved in the T4-TRH regulation mechanism and the hypothesis of a possible positive feedback of T4 at hypothalamic level can, thus, be confirmed.

Keywords

Thyroid Disease Cold Methanol Hypothyroid Patient Hyperthyroid Patient Hypothalamic Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Leonidas Duntas
    • 1
  • Dominique Grouselle
    • 2
  • Fritz S. Keck
    • 1
  • Ulrich Loos
    • 1
  • Ernst F. Pfeiffer
    • 1
  1. 1.Department of Internal Medicine IUniversity of UlmUlmGermany
  2. 2.Groupe de Neuroendocrinologie Cellul.College de FranceParisFrance

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