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Thyrotropin Secretion in Thalassemic Patients during Puberty and Postpuberty

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Frontiers in Thyroidology

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Abstract

Hypogonadotropic hypogonadism attributed to hemosiderosis is frequent in patients with beta-thalassemia major (1,2). Data concerning the other pituitary and peripheral endocrine hormones are controversial. In a previous study (3), we found low thyroid hormone concentrations and/or increased serum TSH levels in a high percentage of clinically euthyroid patients. This situation was found in early childhood and did not change with increasing age. Compensated hypothyroidism with high or normal TSH levels which were hyperresponsive to TRH was described by several authors (4–6) in thalassemic patients, whereas others report normal indices of thyroid function (1,7).

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References

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Author information

Authors and Affiliations

  1. Immunohematology and Transfusional Unit, USL 1, Patologia Medica and Service of Nuclear Medicine of the University, Sassari, Italy

    Maria Langer, Piero P. Rovasio, Antonello Masala, Sergio Alagna, Giovanni A. Cuccuru, Pierangela Cossu, Vittoria Loriga, Giuseppe Madeddu & A. Stangoni

Authors
  1. Maria Langer
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  2. Piero P. Rovasio
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  3. Antonello Masala
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  4. Sergio Alagna
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  5. Giovanni A. Cuccuru
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  6. Pierangela Cossu
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  7. Vittoria Loriga
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  8. Giuseppe Madeddu
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  9. A. Stangoni
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Editor information

Editors and Affiliations

  1. University of São Paulo Medical School, São Paulo, Brazil

    Geraldo Medeiros-Neto M.D. (Professor of Medicine, Secretary General) (Professor of Medicine, Secretary General)

  2. Ninth International Thyroid Congress, São Paulo, Brazil

    Geraldo Medeiros-Neto M.D. (Professor of Medicine, Secretary General) (Professor of Medicine, Secretary General)

  3. University of Mississippi Medical School, Jackson, Mississippi, USA

    Eduardo Gaitan M.D. (Professor of Medicine, Chief) (Professor of Medicine, Chief)

  4. Endocrinology Section, Veterans Administration Medical Center, Jackson, Mississippi, USA

    Eduardo Gaitan M.D. (Professor of Medicine, Chief) (Professor of Medicine, Chief)

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© 1986 Springer Science+Business Media New York

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Langer, M. et al. (1986). Thyrotropin Secretion in Thalassemic Patients during Puberty and Postpuberty. In: Medeiros-Neto, G., Gaitan, E. (eds) Frontiers in Thyroidology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5260-0_44

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  • DOI: https://doi.org/10.1007/978-1-4684-5260-0_44

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5262-4

  • Online ISBN: 978-1-4684-5260-0

  • eBook Packages: Springer Book Archive

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