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Thyrotropin Secretion in Thalassemic Patients during Puberty and Postpuberty

  • Maria Langer
  • Piero P. Rovasio
  • Antonello Masala
  • Sergio Alagna
  • Giovanni A. Cuccuru
  • Pierangela Cossu
  • Vittoria Loriga
  • Giuseppe Madeddu
  • A. Stangoni

Abstract

Hypogonadotropic hypogonadism attributed to hemosiderosis is frequent in patients with beta-thalassemia major (1,2). Data concerning the other pituitary and peripheral endocrine hormones are controversial. In a previous study (3), we found low thyroid hormone concentrations and/or increased serum TSH levels in a high percentage of clinically euthyroid patients. This situation was found in early childhood and did not change with increasing age. Compensated hypothyroidism with high or normal TSH levels which were hyperresponsive to TRH was described by several authors (4–6) in thalassemic patients, whereas others report normal indices of thyroid function (1,7).

Keywords

Thalassemic Patient Hypogonadotropic Hypogonadism Thyrotropin Secretion Puberty Stage Chelate Regimen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Landau H, Spitz IM, Cividalli G, et al. Clin Endocrinol 9: 163, 1978.CrossRefGoogle Scholar
  2. 2.
    Keltzky OA, Costin G, Marrs RP, et al. J Clin Endocrinol Metab 48: 901, 1979.CrossRefGoogle Scholar
  3. 3.
    Madeddu G, Dore A, Marongiu A, et al. Clin Endocrinol 8: 359, 1978.CrossRefGoogle Scholar
  4. 4.
    Cavallo L, Licci D, Acquafredda A, et al. Acta Endocrinol 107: 49, 1984.PubMedGoogle Scholar
  5. 5.
    Flynn MD, Fairey A, Jackson A, et al. Arch Dis Child 51: 828, 1976.CrossRefGoogle Scholar
  6. 6.
    Spitz IM, Hirsch HJ, Landau H, et al. J Endocrinol Invest 7:1980.495Google Scholar
  7. 7.
    De Luca F, Melluso R,Sobbrio G, et al. Arch Dis Child 55: 389, 1980.PubMedCrossRefGoogle Scholar
  8. 8.
    Kuo B, Zaino OE, and Roginsky M. J Clin Endocrinol 28: 805, 1968.CrossRefGoogle Scholar
  9. 9.
    Necheles TF, Chung S, Sabbah R, et al. Ann NY Acad Sci 232: 179, 1974.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Maria Langer
    • 1
  • Piero P. Rovasio
    • 1
  • Antonello Masala
    • 1
  • Sergio Alagna
    • 1
  • Giovanni A. Cuccuru
    • 1
  • Pierangela Cossu
    • 1
  • Vittoria Loriga
    • 1
  • Giuseppe Madeddu
    • 1
  • A. Stangoni
    • 1
  1. 1.Immunohematology and Transfusional Unit, USL 1Patologia Medica and Service of Nuclear Medicine of the UniversitySassariItaly

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