Thyrotropin Secretion in Thalassemic Patients during Puberty and Postpuberty
Hypogonadotropic hypogonadism attributed to hemosiderosis is frequent in patients with beta-thalassemia major (1,2). Data concerning the other pituitary and peripheral endocrine hormones are controversial. In a previous study (3), we found low thyroid hormone concentrations and/or increased serum TSH levels in a high percentage of clinically euthyroid patients. This situation was found in early childhood and did not change with increasing age. Compensated hypothyroidism with high or normal TSH levels which were hyperresponsive to TRH was described by several authors (4–6) in thalassemic patients, whereas others report normal indices of thyroid function (1,7).
KeywordsThalassemic Patient Hypogonadotropic Hypogonadism Thyrotropin Secretion Puberty Stage Chelate Regimen
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- 6.Spitz IM, Hirsch HJ, Landau H, et al. J Endocrinol Invest 7:1980.495Google Scholar