Defective TSH Suppression in a Case of Non-Neoplastic Inappropriate TSH Secretion (ITSHS)
The non-neoplastic inappropriate secretion of thyroid stimulating hormone (ITSHS) classification (1) includes also defective suppression of TSH secretion by somatostatin, dopamine, and other suppressors. These abnormalities have been postulated but not yet, at least contemporarily, documented in any reported case. The present study demonstrates the defective suppression of TSH secretion by dopamine, dopamine agonists, somatostatin, and corticosteroids, and also reports the measurement of plasma immunoreactive endogenous thyrotropin-releasing hormone (TRH) in a patient with ITSHS and thyroid hormone resistance (2).
KeywordsThyroid Hormone Pituitary Adenoma Dopamine Agonist Partial Target Thyroid Hormone Resistance
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