Human Fetal Prolactin but not TSH Secretion is Affected by Dopaminergic Stimuli

  • Elio Roti
  • Giuseppe Robuschi
  • Angelo Gnudi
  • Lewis E. Braverman


In adult mammals, thyrotropin (TSH) is regulated by an integrated system in which circulating thyroid hormones and the intrapituitary conversion of T4 to T3 inhibit and thyrotropin-releasing hormone (TRH) stimulates TSH secretion. Furthermore, somatostatin (SRIH) and dopamine (DA) inhibit pituitary TSH release (1,2). We have reported that TRH (3) and SRIH (4) stimulate and inhibit, respectively, fetal TSH secretion. Metoclopramide, a DA receptor-blocking drug, given to parturient women does not affect cord blood (CB) TSH, suggesting that DA plays a minor role in the regulation of fetal TSH secretion (5). We have now investigated the effect of bromocriptine (BC), a DA agonist drug, given to women during labor on TSH and prolactin (PRL) secretion in the term fetus.


Maternal Serum Endocrinol Invest Circulate Thyroid Hormone Parturient Woman Maternal Administration 


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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Elio Roti
    • 1
    • 2
  • Giuseppe Robuschi
    • 1
    • 2
  • Angelo Gnudi
    • 1
    • 2
  • Lewis E. Braverman
    • 1
    • 2
  1. 1.University of Parma Medical SchoolItaly
  2. 2.University of Massachusetts Medical SchoolWorcesterUSA

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