Perinatal Pituitary-Thyroid Function at High Altitude

  • Arturo Villena
  • Eduardo A. Pretell
  • Eduardo Manucci
  • Emilia Wong


Acute exposure of adult men to a high altitude environment results in transitory thyroid hyperactivity (1) and increased TSH secretion (2). The effect of high altitude on pituitary-thyroid function during perinatal life has little been studied. Normal low cord blood T4 levels have been reported (3), and a hypoxemic condition of the fetus has been suggested by high cord blood hematocrits (4), hyperplasia of bone marrow erythroid cells (5), lower birth weight (6), and by a higher incidence of prematurity (6) and neonatal mortality (7).


Thyroid Hormone High Altitude Cord Blood Placental Weight Newborn Child 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Pretell EA, Llerena LA, et al. Abstracto II Congreso Bolivariano de Endocrinologia, Caracas, Venezuela, Oct. 1971, p 41.Google Scholar
  2. 2.
    Mordes J, Blume FD, et al. N Engl J Med 308: 1135, 1983.PubMedCrossRefGoogle Scholar
  3. 3.
    Pretell EA, Abuid J, and Cateriano M. VII Jornadas Peruanas de Endocrinologia, Ica, Peru, Oct. 1977, p 42.Google Scholar
  4. 4.
    Loret de Mola L. Tesis de Bachiller, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Peru, 1955.Google Scholar
  5. 5.
    Reynafarje C. J Pediatr 54: 152, 1959.PubMedCrossRefGoogle Scholar
  6. 6.
    Lichty JA, Ting RY, et al. Am J Dis Chil 93: 666, 1957.Google Scholar
  7. 7.
    Grahn D and Kratchman J. Am J Human Genet 15: 329, 1963.Google Scholar
  8. 8.
    Fisher DA and Odell WD. J Clin Invest 48: 1670, 1969.PubMedCrossRefGoogle Scholar
  9. 9.
    Abuid J, Stinson DA, and Larsen R. J Clin Invest 52: 1195, 1973.PubMedCrossRefGoogle Scholar
  10. 10.
    Fisher DA, Dussault J, et al. Prg Hormone Res 33: 59, 1977.Google Scholar
  11. 11.
    Spencer CA and Nicoloff JT. Clin Chim Acta 108: 415, 1980.PubMedCrossRefGoogle Scholar
  12. 12.
    Challand GS, Ratcliffe WA, and Ratcliffe JG. Clin Chim Acta 60: 25, 1975PubMedCrossRefGoogle Scholar
  13. 13.
    Ekins RP. In RP Ekins (ed), Methods for the Measurement of Free Thyroid Hormones, Excerpta Medica, Ambsterdam, 1979.Google Scholar
  14. 14.
    Apgar V, Holaday, DA, et al. JAMA 168: 1985, 1958.Google Scholar
  15. 15.
    Dubowitz L, Dubowitz V, and Goldberg C. J Pediatr 77: 1, 1970.PubMedCrossRefGoogle Scholar
  16. 16.
    Kadar K. Revista Peruana Ginecologia y Obstetrica 27: 3, 1971.Google Scholar
  17. 17.
    Mc Gover JJ, Jones AR, and Steimberg AG. J Med 252: 253, 1955.Google Scholar
  18. 18.
    Jolin T and Escobar del Rey F. J Clin Endocrinol Metab 25: 540, 1965.PubMedCrossRefGoogle Scholar
  19. 19.
    Eremberg A, Phelps DL, et al. Pediatrics 32: 211, 1974.Google Scholar
  20. 20.
    Wu S-Y, Klein AH, et al. Endocrinology 103: 235, 1978.PubMedCrossRefGoogle Scholar
  21. 21.
    Jacobsen BB, Anderson HJ, et al. Acta Paediatr Scand 66: 681, 1977.PubMedCrossRefGoogle Scholar
  22. 22.
    Scammel J, Barney C, and Fregly M. J Appl Physiol 51 (5): 1157, 1981.Google Scholar
  23. 23.
    Sobrevilla LA, Casinelli MT, et al. Am J Obst Gynec 111: 1111, 1971.Google Scholar
  24. 24.
    Dunn JT. In JB Stanbury and RL Kroc (eds), Human Development and the Thyroid Gland, Plenum Press, New York, 1972, p 367.Google Scholar
  25. 25.
    Reddings RA, Douglas WH, and Stein M. Science 1975: 994, 1972.Google Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Arturo Villena
    • 1
  • Eduardo A. Pretell
    • 1
  • Eduardo Manucci
    • 1
  • Emilia Wong
    • 1
  1. 1.Endocrine Laboratory, High Altitude Research Institute and Pediatrics ServiceHospital Cayetano Heredia and Universidad Cayetano HerediaLimaPeru

Personalised recommendations