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TSH Secretory Regulation: New Evidence that Triiodothyronine (T3) and Thyroxine (T4) Can Inhibit TRH Secretion Both in Vivo and in Vitro

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Frontiers in Thyroidology

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Abstract

The potential influence of thyroid hormones in vivo upon TRH secretion was examined using rat hypothalami in vitro derived from hyperthyroid (50 μg L-T4/100 g.B.W. x 4 days) and hypothyroid (4 weeks post total thyroid­ectomy) rats. Ouabain-activated TRH secretion from hypothalami derived from hyperthyroid animals was lowered in 14 + 3.7%, significant at p<0.02, and TRH secretion stimulated by ouabain was augmented 36 + 10% from hypo-thyroid hypothalami. Similarly, when L-triiodothyronine (T3) (0.1 μg/100 g.B.W.) was injected intraventricularly, serum TSH was lowered significantly without a concomitant elevation in peripheral T3 concentrations. In con­trast, administration of the identical quantity of T3 i.p. had no suppres­sive effect upon TSH release. It is concluded that thyroid hormones regu­late TSH secretion, at least in part, by inhibition of hypothalamic TRH secretion directly.

Supported in part by USPHS Grant #NS 19885.

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Authors and Affiliations

  1. Section of Endocrinology, Department of Medicine, LSU Medical Center, New Orleans, LA, USA

    Tokuji Iriuchijima, Debbie Rogers & John F. Wilber

Authors
  1. Tokuji Iriuchijima
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  2. Debbie Rogers
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  3. John F. Wilber
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Editor information

Editors and Affiliations

  1. University of São Paulo Medical School, São Paulo, Brazil

    Geraldo Medeiros-Neto M.D. (Professor of Medicine, Secretary General) (Professor of Medicine, Secretary General)

  2. Ninth International Thyroid Congress, São Paulo, Brazil

    Geraldo Medeiros-Neto M.D. (Professor of Medicine, Secretary General) (Professor of Medicine, Secretary General)

  3. University of Mississippi Medical School, Jackson, Mississippi, USA

    Eduardo Gaitan M.D. (Professor of Medicine, Chief) (Professor of Medicine, Chief)

  4. Endocrinology Section, Veterans Administration Medical Center, Jackson, Mississippi, USA

    Eduardo Gaitan M.D. (Professor of Medicine, Chief) (Professor of Medicine, Chief)

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© 1986 Springer Science+Business Media New York

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Iriuchijima, T., Rogers, D., Wilber, J.F. (1986). TSH Secretory Regulation: New Evidence that Triiodothyronine (T3) and Thyroxine (T4) Can Inhibit TRH Secretion Both in Vivo and in Vitro. In: Medeiros-Neto, G., Gaitan, E. (eds) Frontiers in Thyroidology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5260-0_37

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  • DOI: https://doi.org/10.1007/978-1-4684-5260-0_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5262-4

  • Online ISBN: 978-1-4684-5260-0

  • eBook Packages: Springer Book Archive

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