TSH Secretory Regulation: New Evidence that Triiodothyronine (T3) and Thyroxine (T4) Can Inhibit TRH Secretion Both in Vivo and in Vitro

  • Tokuji Iriuchijima
  • Debbie Rogers
  • John F. Wilber


The potential influence of thyroid hormones in vivo upon TRH secretion was examined using rat hypothalami in vitro derived from hyperthyroid (50 μg L-T4/100 g.B.W. x 4 days) and hypothyroid (4 weeks post total thyroid­ectomy) rats. Ouabain-activated TRH secretion from hypothalami derived from hyperthyroid animals was lowered in 14 + 3.7%, significant at p<0.02, and TRH secretion stimulated by ouabain was augmented 36 + 10% from hypo-thyroid hypothalami. Similarly, when L-triiodothyronine (T3) (0.1 μg/100 g.B.W.) was injected intraventricularly, serum TSH was lowered significantly without a concomitant elevation in peripheral T3 concentrations. In con­trast, administration of the identical quantity of T3 i.p. had no suppres­sive effect upon TSH release. It is concluded that thyroid hormones regu­late TSH secretion, at least in part, by inhibition of hypothalamic TRH secretion directly.


Thyroid Hormone Euthyroid Control Concomitant Elevation Hyperthyroid Animal Thyrotroph Cell 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Tokuji Iriuchijima
    • 1
  • Debbie Rogers
    • 1
  • John F. Wilber
    • 1
  1. 1.Section of Endocrinology, Department of MedicineLSU Medical CenterNew OrleansUSA

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