Evaluation of Patients on Thyroxine (T4) Replacement with a Highly Sensitive Commercial TSH Immunoradiometric Assay (TSH-IRMA)

  • Juan Garces
  • Charles P. Barsano


Current strategies for the optimal management of patients requiring thyroid hormone replacement or suppression therapy are limited by the nonspecificity and insensitivity of clinical symptoms and by the impracticality of frequent or extensive laboratory evaluation of thyroid status (e.g., TSH testing, radioiodine uptake). The recent introduction of highly sensitive TSH assays which distinguish suppressed from normal TSH levels offers a practical means for applying more precise assessment of basal TSH secretion. This study was conducted to illustrate the potential for under- or over-medication of patients receiving T4 replacement or T4 suppression when managed conventionally and to suggest a practical strategy for improved management employing sensitive TSH measurement.


Radioiodine Uptake Alter Thyroid Hormone High Sensitivity Serum Thyroid Hormone Binding Protein 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Juan Garces
    • 1
  • Charles P. Barsano
    • 1
  1. 1.Center for Endocrinology, Metabolism and NutritionNorthwestern University and VA Lakeside Medical CenterChicagoUSA

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